%0 Journal Article
%@ 0025-7931 (Druck-Ausg.); 1423-0356 (Online-Ausg.)
%A Lindner, Simon
%A Teichert, Jan
%A Hoermann, Clara
%A Michels, Julia D.
%A Herth, Felix J.F.
%A Duerschmied, Daniel
%A Britsch, Simone
%C Basel ; Freiburg [u.a.]
%D 2024
%F heidok:36564
%I Karger
%J Respiration
%K Diaphragm thickening fraction, Ultrasound,  Respiratory effort, Non-invasive ventilation, Continuous positive airway pressure
%N 2
%P 100-104
%R 10.11588/heidok.00036564
%T Mask Continuous Positive Airway Pressure Increases Diaphragm Thickening Fraction in Healthy Subjects
%U https://archiv.ub.uni-heidelberg.de/volltextserver/36564/
%V 103
%X Introduction: The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). The addition of inspiratory support is a potential alternative. This is a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by diaphragm thickening fraction (DTF) in healthy volunteers. Methods: DTF was measured in spontaneously breathing, healthy volunteers during 4 phases: (I) without connection to a ventilator, (II) on a ventilator without any applied pressures, (III) with a CPAP of 5 cmH2O, and (IV) with an additional inspiratory support pressure of 5 cmH2O. Results: Twenty-nine individuals agreed to participate. DTF was similar during the first two phases (32 ± 13% and 35 ± 22%). A considerable increase in DTF to 51 ± 21% was noted in phase III. The introduction of inspiratory support pressure during phase IV led to a reduction in DTF back to 36 ± 23% (p < 0.001). Tidal volume and minute ventilation were both slightly higher in phase IV compared to phase III. Conclusion: CPAP without inspiratory support pressure increases respiratory effort measured by DTF in healthy subjects. Further research is required to investigate this phenomenon in a clinical setting.
%Z Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively