eprintid: 36564
rev_number: 13
eprint_status: archive
userid: 5878
dir: disk0/00/03/65/64
datestamp: 2025-05-15 12:27:05
lastmod: 2025-05-26 17:42:54
status_changed: 2025-05-15 12:27:05
type: article
metadata_visibility: show
creators_name: Lindner, Simon
creators_name: Teichert, Jan
creators_name: Hoermann, Clara
creators_name: Michels, Julia D.
creators_name: Herth, Felix J.F.
creators_name: Duerschmied, Daniel
creators_name: Britsch, Simone
title: Mask Continuous Positive Airway Pressure Increases Diaphragm Thickening Fraction in Healthy Subjects
ispublished: pub
subjects: ddc-610
divisions: i-61000
divisions: i-910100
divisions: i-950900
keywords: Diaphragm thickening fraction, Ultrasound,  Respiratory effort, Non-invasive ventilation, Continuous positive airway pressure
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively
abstract: Introduction: The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). The addition of inspiratory support is a potential alternative. This is a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by diaphragm thickening fraction (DTF) in healthy volunteers. Methods: DTF was measured in spontaneously breathing, healthy volunteers during 4 phases: (I) without connection to a ventilator, (II) on a ventilator without any applied pressures, (III) with a CPAP of 5 cmH2O, and (IV) with an additional inspiratory support pressure of 5 cmH2O. Results: Twenty-nine individuals agreed to participate. DTF was similar during the first two phases (32 ± 13% and 35 ± 22%). A considerable increase in DTF to 51 ± 21% was noted in phase III. The introduction of inspiratory support pressure during phase IV led to a reduction in DTF back to 36 ± 23% (p < 0.001). Tidal volume and minute ventilation were both slightly higher in phase IV compared to phase III. Conclusion: CPAP without inspiratory support pressure increases respiratory effort measured by DTF in healthy subjects. Further research is required to investigate this phenomenon in a clinical setting.
date: 2024
date_type: published
publisher: Karger
id_scheme: DOI
id_number: 10.11588/heidok.00036564
official_url: https://doi.org/10.1159/000535990
ppn_swb: 192664784X
own_urn: urn:nbn:de:bsz:16-heidok-365645
language: eng
bibsort: LINDNERSIMMASKCONTIN2024
full_text_status: public
publication: Respiration
volume: 103
number: 2
place_of_pub: Basel ; Freiburg [u.a.]
pagerange: 100-104
pages: 5
issn: 0025-7931 (Druck-Ausg.); 1423-0356 (Online-Ausg.)
edition: Zweitveröffentlichung
citation:   Lindner, Simon ; Teichert, Jan ; Hoermann, Clara ; Michels, Julia D. ; Herth, Felix J.F. ; Duerschmied, Daniel ; Britsch, Simone  (2024) Mask Continuous Positive Airway Pressure Increases Diaphragm Thickening Fraction in Healthy Subjects.  Respiration, 103 (2).  pp. 100-104.  ISSN 0025-7931 (Druck-Ausg.); 1423-0356 (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/36564/1/RES535990.pdf