title: Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population – The Tongren Health Care Study
creator: Gao, Li Qin
creator: Xue, Can Can
creator: Cui, Jing
creator: Xu, Jie
creator: Zhang, Chun
creator: Chen, Dong Ning
creator: Jonas, Jost B.
creator: Wang, Ya Xing
description: Introduction: The aim of the study was to investigate associations between diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with type 2 diabetes (TD2). Methods: The participants of the cross-sectional, community-based Tongren Health Care Study underwent a detailed medical and ophthalmological examination. We defined TD2 by a fasting plasma glucose concentration of ≥7.0 mmol/L or a medical history. CKD was classified as either reduced estimated glomerular filtration rate (eGFR) of &lt;60 mL/min/1.73 mm<sup>2</sup> or presence of albuminuria. DR was assessed using color fundus photographs. Results: Out of 62,217 participants of the Tongren Health Care Study, 5,103 (8.2%) patients had TD2. The prevalence of DR was 12.8% (95% CI, 11.8%, 13.7%), CKD was 13.3% (95% CI, 12.4%, 14.3%), and the subtypes of CKD including reduced eGFR and albuminuria was 4.6% (95% CI, 4.2%, 5.1%) and 10.1% (95% CI, 9.3%, 10.9%), respectively. DR was detectable in 21.0% of the patients with CKD, while CKD was present in 20.9% of the DR patients. Higher DR prevalence was associated with higher prevalence of albuminuria and reduced eGFR (both <i>p</i> &lt; 0.05). Factors independently associated with the presence of CKD instead of DR were older age (<i>p</i> &lt; 0.001, OR = 1.05), a higher body mass index (<i>p</i> &lt; 0.001, OR = 1.14), a higher serum concentration of triglycerides (<i>p</i> &lt; 0.001, OR = 1.26), and a lower blood glucose (<i>p</i> &lt; 0.001, OR = 0.93). Having hypertension was additionally associated with the presence of reduced eGFR as compared with DR (<i>p</i> = 0.005, OR = 4.47). <b><i>Conclusions:</i></b> TD2 patients of older age and with higher body mass index, hypertension, and dyslipidemia had a higher probability of being affected by CKD rather than DR, while those with a higher blood glucose level were more prone to DR than CKD.
publisher: Karger
date: 2024
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/36574/1/AJN535059.pdf
identifier: DOI:10.11588/heidok.00036574
identifier: https://doi.org/10.1159/000535059
identifier: urn:nbn:de:bsz:16-heidok-365746
identifier:   Gao, Li Qin ; Xue, Can Can ; Cui, Jing ; Xu, Jie ; Zhang, Chun ; Chen, Dong Ning ; Jonas, Jost B. ; Wang, Ya Xing  (2024) Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population – The Tongren Health Care Study.  American Journal of Nephrology, 55 (2).  pp. 175-186.  ISSN 0250-8095 (Druck-Ausg.); 1421-9670 (Online-Ausg.)     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/36574/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng