eprintid: 36574
rev_number: 10
eprint_status: archive
userid: 5878
dir: disk0/00/03/65/74
datestamp: 2025-05-16 10:23:51
lastmod: 2025-05-27 10:46:07
status_changed: 2025-05-16 10:23:51
type: article
metadata_visibility: show
creators_name: Gao, Li Qin
creators_name: Xue, Can Can
creators_name: Cui, Jing
creators_name: Xu, Jie
creators_name: Zhang, Chun
creators_name: Chen, Dong Ning
creators_name: Jonas, Jost B.
creators_name: Wang, Ya Xing
title: Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population – The Tongren Health Care Study
ispublished: pub
divisions: i-61700
keywords: Type 2 diabetes, Diabetic retinopathy, Chronic kidney disease, Diabetic microvascular complication, Albuminuria, Estimated glomerular filtration rate, Albumin-to-creatinine ratio
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
abstract: Introduction: The aim of the study was to investigate associations between diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with type 2 diabetes (TD2). Methods: The participants of the cross-sectional, community-based Tongren Health Care Study underwent a detailed medical and ophthalmological examination. We defined TD2 by a fasting plasma glucose concentration of ≥7.0 mmol/L or a medical history. CKD was classified as either reduced estimated glomerular filtration rate (eGFR) of &lt;60 mL/min/1.73 mm<sup>2</sup> or presence of albuminuria. DR was assessed using color fundus photographs. Results: Out of 62,217 participants of the Tongren Health Care Study, 5,103 (8.2%) patients had TD2. The prevalence of DR was 12.8% (95% CI, 11.8%, 13.7%), CKD was 13.3% (95% CI, 12.4%, 14.3%), and the subtypes of CKD including reduced eGFR and albuminuria was 4.6% (95% CI, 4.2%, 5.1%) and 10.1% (95% CI, 9.3%, 10.9%), respectively. DR was detectable in 21.0% of the patients with CKD, while CKD was present in 20.9% of the DR patients. Higher DR prevalence was associated with higher prevalence of albuminuria and reduced eGFR (both <i>p</i> &lt; 0.05). Factors independently associated with the presence of CKD instead of DR were older age (<i>p</i> &lt; 0.001, OR = 1.05), a higher body mass index (<i>p</i> &lt; 0.001, OR = 1.14), a higher serum concentration of triglycerides (<i>p</i> &lt; 0.001, OR = 1.26), and a lower blood glucose (<i>p</i> &lt; 0.001, OR = 0.93). Having hypertension was additionally associated with the presence of reduced eGFR as compared with DR (<i>p</i> = 0.005, OR = 4.47). <b><i>Conclusions:</i></b> TD2 patients of older age and with higher body mass index, hypertension, and dyslipidemia had a higher probability of being affected by CKD rather than DR, while those with a higher blood glucose level were more prone to DR than CKD.
date: 2024
date_type: published
publisher: Karger
id_scheme: DOI
id_number: 10.11588/heidok.00036574
official_url: https://doi.org/10.1159/000535059
ppn_swb: 1926703685
own_urn: urn:nbn:de:bsz:16-heidok-365746
language: eng
bibsort: GAOLIQINDIABETICRE2024
full_text_status: public
publication: American Journal of Nephrology
volume: 55
number: 2
place_of_pub: Basel [u.a.]
pagerange: 175-186
pages: 12
issn: 0250-8095 (Druck-Ausg.); 1421-9670 (Online-Ausg.)
edition: Zweitveröffentlichung
citation:   Gao, Li Qin ; Xue, Can Can ; Cui, Jing ; Xu, Jie ; Zhang, Chun ; Chen, Dong Ning ; Jonas, Jost B. ; Wang, Ya Xing  (2024) Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population – The Tongren Health Care Study.  American Journal of Nephrology, 55 (2).  pp. 175-186.  ISSN 0250-8095 (Druck-Ausg.); 1421-9670 (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/36574/1/AJN535059.pdf