title: Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma
creator: Walach, Margarete Teresa
creator: Nitschke, Katja
creator: Groß-Weege, Matthias
creator: Großhans, Johannes
creator: Wildner, Lukas
creator: Pause, Luca
creator: Jarczyk, Jonas
creator: Wessels, Frederik
creator: Neuberger, Manuel
creator: Kowalewski, Karl-Friedrich
creator: Kriegmair, Maximilian Christian
creator: Popovic, Zoran V.
creator: Gaiser, Timo
creator: Worst, Thomas Stefan
creator: Nuhn, Philipp
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Introduction:The aim was to evaluate the prognostic value of altered <i>Cyclin A2 (CCNA2)</i> gene expression in upper tract urothelial carcinoma (UTUC) and to assess its predictive potential as a prognostic factor for overall survival (OS) and disease-free survival. Methods: 62 patients who underwent surgical treatment for UTUC were included. Gene expression of <i>CCNA2</i>, <i>MKI67</i>, and <i>p53</i> was analyzed by quantitative reverse transcriptase polymerase chain reaction. Survival analyses were performed using the Kaplan-Meier method and the log-rank test. For Cox regression analyses, uni- and multivariable hazard ratios were calculated. Spearman correlation was used to analyze correlation of <i>CCNA2</i> expression with <i>MKI67</i> and <i>p53</i>. <b><i>Results: The median age of the cohort was 73 years, and it consisted of 48 males (77.4%) and 14 females (22.6%). Patients with high <i>CCNA2</i> expression levels showed longer OS (HR 0.33; 95% CI: 0.15–0.74; <i>p</i> = 0.0073). Multivariable Cox regression analyses identified <i>CCNA2</i> overexpression (HR 0.37; 95% CI: 0.16–0.85; <i>p</i> = 0.0189) and grading G2 (vs. G3) (HR 0.39; 95% CI: 0.17–0.87; <i>p</i> = 0.0168) to be independent predictors for longer OS. <i>CCNA2</i> expression correlated positively with <i>MKI67</i> expression (Rho = 0.4376, <i>p</i> = 0.0005). Conclusion:Low <i>CCNA2</i> expression is significantly associated with worse OS. Thus, <i>CCNA2</i> might serve as a potential biomarker in muscle-invasive UTUC and may be used to characterize a subset of patients having an unfavorable outcome and for future risk assessment scores.
publisher: Karger
date: 2024
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/36577/1/UIN536184.pdf
identifier: DOI:10.11588/heidok.00036577
identifier: https://doi.org/10.1159/000536184
identifier: urn:nbn:de:bsz:16-heidok-365773
identifier:   Walach, Margarete Teresa ; Nitschke, Katja ; Groß-Weege, Matthias ; Großhans, Johannes ; Wildner, Lukas ; Pause, Luca ; Jarczyk, Jonas ; Wessels, Frederik ; Neuberger, Manuel ; Kowalewski, Karl-Friedrich ; Kriegmair, Maximilian Christian ; Popovic, Zoran V. ; Gaiser, Timo ; Worst, Thomas Stefan ; Nuhn, Philipp  (2024) Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma.  Urologia Internationalis, 108 (2).  pp. 128-136.  ISSN 0042-1138 (Druck-Ausg.); 1423-0399 (Online-Ausg.)     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/36577/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng