TY  - JOUR
AV  - public
TI  - Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma
SP  - 128
PB  - Karger
Y1  - 2024///
IS  - 2
JF  - Urologia Internationalis
KW  - Cyclin A2
KW  -  Upper tract urothelial carcinoma
KW  -  Biomarker
KW  -  Overall survival
N2  - Introduction:The aim was to evaluate the prognostic value of altered <i>Cyclin A2 (CCNA2)</i> gene expression in upper tract urothelial carcinoma (UTUC) and to assess its predictive potential as a prognostic factor for overall survival (OS) and disease-free survival. Methods: 62 patients who underwent surgical treatment for UTUC were included. Gene expression of <i>CCNA2</i>, <i>MKI67</i>, and <i>p53</i> was analyzed by quantitative reverse transcriptase polymerase chain reaction. Survival analyses were performed using the Kaplan-Meier method and the log-rank test. For Cox regression analyses, uni- and multivariable hazard ratios were calculated. Spearman correlation was used to analyze correlation of <i>CCNA2</i> expression with <i>MKI67</i> and <i>p53</i>. <b><i>Results: The median age of the cohort was 73 years, and it consisted of 48 males (77.4%) and 14 females (22.6%). Patients with high <i>CCNA2</i> expression levels showed longer OS (HR 0.33; 95% CI: 0.15?0.74; <i>p</i> = 0.0073). Multivariable Cox regression analyses identified <i>CCNA2</i> overexpression (HR 0.37; 95% CI: 0.16?0.85; <i>p</i> = 0.0189) and grading G2 (vs. G3) (HR 0.39; 95% CI: 0.17?0.87; <i>p</i> = 0.0168) to be independent predictors for longer OS. <i>CCNA2</i> expression correlated positively with <i>MKI67</i> expression (Rho = 0.4376, <i>p</i> = 0.0005). Conclusion:Low <i>CCNA2</i> expression is significantly associated with worse OS. Thus, <i>CCNA2</i> might serve as a potential biomarker in muscle-invasive UTUC and may be used to characterize a subset of patients having an unfavorable outcome and for future risk assessment scores.
EP  - 136
VL  - 108
ID  - heidok36577
SN  - 0042-1138 (Druck-Ausg.); 1423-0399 (Online-Ausg.)
CY  - Basel [u.a.]
A1  - Walach, Margarete Teresa
A1  - Nitschke, Katja
A1  - Groß-Weege, Matthias
A1  - Großhans, Johannes
A1  - Wildner, Lukas
A1  - Pause, Luca
A1  - Jarczyk, Jonas
A1  - Wessels, Frederik
A1  - Neuberger, Manuel
A1  - Kowalewski, Karl-Friedrich
A1  - Kriegmair, Maximilian Christian
A1  - Popovic, Zoran V.
A1  - Gaiser, Timo
A1  - Worst, Thomas Stefan
A1  - Nuhn, Philipp
UR  - https://doi.org/10.1159/000536184
N1  - Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
ER  -