eprintid: 36577
rev_number: 12
eprint_status: archive
userid: 5878
dir: disk0/00/03/65/77
datestamp: 2025-05-16 11:34:43
lastmod: 2025-05-27 11:12:51
status_changed: 2025-05-16 11:34:43
type: article
metadata_visibility: show
creators_name: Walach, Margarete Teresa
creators_name: Nitschke, Katja
creators_name: Groß-Weege, Matthias
creators_name: Großhans, Johannes
creators_name: Wildner, Lukas
creators_name: Pause, Luca
creators_name: Jarczyk, Jonas
creators_name: Wessels, Frederik
creators_name: Neuberger, Manuel
creators_name: Kowalewski, Karl-Friedrich
creators_name: Kriegmair, Maximilian Christian
creators_name: Popovic, Zoran V.
creators_name: Gaiser, Timo
creators_name: Worst, Thomas Stefan
creators_name: Nuhn, Philipp
title: Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma
ispublished: pub
subjects: ddc-610
divisions: i-63100
divisions: i-63400
keywords: Cyclin A2, Upper tract urothelial carcinoma, Biomarker, Overall survival
note: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
abstract: Introduction:The aim was to evaluate the prognostic value of altered <i>Cyclin A2 (CCNA2)</i> gene expression in upper tract urothelial carcinoma (UTUC) and to assess its predictive potential as a prognostic factor for overall survival (OS) and disease-free survival. Methods: 62 patients who underwent surgical treatment for UTUC were included. Gene expression of <i>CCNA2</i>, <i>MKI67</i>, and <i>p53</i> was analyzed by quantitative reverse transcriptase polymerase chain reaction. Survival analyses were performed using the Kaplan-Meier method and the log-rank test. For Cox regression analyses, uni- and multivariable hazard ratios were calculated. Spearman correlation was used to analyze correlation of <i>CCNA2</i> expression with <i>MKI67</i> and <i>p53</i>. <b><i>Results: The median age of the cohort was 73 years, and it consisted of 48 males (77.4%) and 14 females (22.6%). Patients with high <i>CCNA2</i> expression levels showed longer OS (HR 0.33; 95% CI: 0.15–0.74; <i>p</i> = 0.0073). Multivariable Cox regression analyses identified <i>CCNA2</i> overexpression (HR 0.37; 95% CI: 0.16–0.85; <i>p</i> = 0.0189) and grading G2 (vs. G3) (HR 0.39; 95% CI: 0.17–0.87; <i>p</i> = 0.0168) to be independent predictors for longer OS. <i>CCNA2</i> expression correlated positively with <i>MKI67</i> expression (Rho = 0.4376, <i>p</i> = 0.0005). Conclusion:Low <i>CCNA2</i> expression is significantly associated with worse OS. Thus, <i>CCNA2</i> might serve as a potential biomarker in muscle-invasive UTUC and may be used to characterize a subset of patients having an unfavorable outcome and for future risk assessment scores.
date: 2024
date_type: published
publisher: Karger
id_scheme: DOI
id_number: 10.11588/heidok.00036577
official_url: https://doi.org/10.1159/000536184
ppn_swb: 1926810988
own_urn: urn:nbn:de:bsz:16-heidok-365773
language: eng
bibsort: WALACHMARGCYCLINA2EX2024
full_text_status: public
publication: Urologia Internationalis
volume: 108
number: 2
place_of_pub: Basel [u.a.]
pagerange: 128-136
pages: 9
issn: 0042-1138 (Druck-Ausg.); 1423-0399 (Online-Ausg.)
edition: Zweitveröffentlichung
citation:   Walach, Margarete Teresa ; Nitschke, Katja ; Groß-Weege, Matthias ; Großhans, Johannes ; Wildner, Lukas ; Pause, Luca ; Jarczyk, Jonas ; Wessels, Frederik ; Neuberger, Manuel ; Kowalewski, Karl-Friedrich ; Kriegmair, Maximilian Christian ; Popovic, Zoran V. ; Gaiser, Timo ; Worst, Thomas Stefan ; Nuhn, Philipp  (2024) Cyclin A2 Expression as Predictive Biomarker in Muscle-Invasive Upper Tract Urothelial Carcinoma.  Urologia Internationalis, 108 (2).  pp. 128-136.  ISSN 0042-1138 (Druck-Ausg.); 1423-0399 (Online-Ausg.)     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/36577/1/UIN536184.pdf