title: Proteogenomics of Treatment Resistant Osteosarcoma
creator: Frenz, Joris Maximilian
subject: ddc-570
subject: 570 Life sciences
subject: ddc-600
subject: 600 Technology (Applied sciences)
description: Osteosarcoma (OS) is the most common form of primary malignant bone cancer, predominantly  affecting children and young adults. Despite extensive research at the genomic and transcriptomic  levels, advances in the treatment of OS have been limited, and patients with treatment-resistant OS  continue to face particularly poor overall survival rates. This thesis presents a comprehensive multiomics analysis aimed at identifying the targetable proteomic landscape of treatment-resistant OS.  Through unbiased mass spectrometry-based proteomic profiling, I identified three distinct subtypes  of treatment-resistant OS, each associated with varying survival outcomes. Notably, in one subtype  associated with poor overall survival, upregulation of MYC signalling and MYC activity emerged as  prominent features. Subsequent in vitro experiments targeting this subtype through inhibition of MYC  kinases CDK2 and CDK5 demonstrated potential therapeutic benefits. Overall, this work provides a  detailed multi-omics characterization of treatment-resistant OS, offering insights into novel  therapeutic options that may improve patient outcomes.
date: 2025
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/36797/1/Proteogenomics_of_Treatment_Resistant_Osteosarcoma_final.pdf
identifier: DOI:10.11588/heidok.00036797
identifier: urn:nbn:de:bsz:16-heidok-367978
identifier:   Frenz, Joris Maximilian  (2025) Proteogenomics of Treatment Resistant Osteosarcoma.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/36797/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng