<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Proteogenomics of Treatment Resistant Osteosarcoma"^^ . "Osteosarcoma (OS) is the most common form of primary malignant bone cancer, predominantly\r\naffecting children and young adults. Despite extensive research at the genomic and transcriptomic\r\nlevels, advances in the treatment of OS have been limited, and patients with treatment-resistant OS\r\ncontinue to face particularly poor overall survival rates. This thesis presents a comprehensive multiomics analysis aimed at identifying the targetable proteomic landscape of treatment-resistant OS.\r\nThrough unbiased mass spectrometry-based proteomic profiling, I identified three distinct subtypes\r\nof treatment-resistant OS, each associated with varying survival outcomes. Notably, in one subtype\r\nassociated with poor overall survival, upregulation of MYC signalling and MYC activity emerged as\r\nprominent features. Subsequent in vitro experiments targeting this subtype through inhibition of MYC\r\nkinases CDK2 and CDK5 demonstrated potential therapeutic benefits. Overall, this work provides a\r\ndetailed multi-omics characterization of treatment-resistant OS, offering insights into novel\r\ntherapeutic options that may improve patient outcomes."^^ . "2025" . . . . . . . "Joris Maximilian"^^ . "Frenz"^^ . "Joris Maximilian Frenz"^^ . . . . . . "Proteogenomics of Treatment Resistant Osteosarcoma (PDF)"^^ . . . "Proteogenomics of Treatment Resistant Osteosarcoma (Other)"^^ . . . . . . "Proteogenomics of Treatment Resistant Osteosarcoma (Other)"^^ . . . . . . "Proteogenomics of Treatment Resistant Osteosarcoma (Other)"^^ . . . . . . "Proteogenomics of Treatment Resistant Osteosarcoma (Other)"^^ . . . . . . "Proteogenomics of Treatment Resistant Osteosarcoma (Other)"^^ . . . . . "HTML Summary of #36797 \n\nProteogenomics of Treatment Resistant Osteosarcoma\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . . . "600 Technik, Medizin, angewandte Wissenschaften"@de . "600 Technology (Applied sciences)"@en . .