eprintid: 37074 rev_number: 12 eprint_status: archive userid: 9204 dir: disk0/00/03/70/74 datestamp: 2025-08-07 12:16:10 lastmod: 2025-08-11 16:10:09 status_changed: 2025-08-07 12:16:10 type: doctoralThesis metadata_visibility: show creators_name: Hütsch, Nathan Karl title: Generative Machine Learning for Simulation-based Inference in High Energy Physics subjects: ddc-530 divisions: i-130300 adv_faculty: af-13 abstract: With the upcoming High-Luminosity LHC the volume of collider data will increase dramatically, leading to a new era of precision measurements. However, this also creates computational and methodological challenges. Established simulation and inference pipelines require significant upgrades to prevent them from becoming bottlenecks. This thesis investigates how generative machine learning can address these challenges. First, we investigate modern generative architectures, diffusion models and autoregressive transformers, for fast and accurate LHC event generation. We find that they can learn complex phase space distributions to percent-level precision, demonstrating their potential as surrogate simulators. Second, we advance the use of machine learning for the matrix element method, showing how generative networks can be used to encode the transfer probability and keep the phase space integration tractable. Finally, we explore high-dimensional, unbinned unfolding using generative models. We benchmark the performance of a range of methods on the same datasets and contribute several methodological advancements, including a transformer-enhanced diffusion model that achieves state-of-the-art precision. date: 2025 id_scheme: DOI id_number: 10.11588/heidok.00037074 ppn_swb: 1932967834 own_urn: urn:nbn:de:bsz:16-heidok-370745 date_accepted: 2025-07-04 advisor: HASH(0x55602a6b6f38) language: eng bibsort: HUTSCHNATHGENERATIVE20250422 full_text_status: public place_of_pub: Heidelberg citation: Hütsch, Nathan Karl (2025) Generative Machine Learning for Simulation-based Inference in High Energy Physics. [Dissertation] document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/37074/1/phd_thesis.pdf