title: Influence of field strength on quantitative parameters and feature stability in the assessment of the ovaries using 1.5-T and 3-T MRI
creator: Mokry, Theresa
creator: Pantke, Judith
creator: Kauczor, Hans-Ulrich
creator: Laun, Frederik B
creator: Schlemmer, Heinz-Peter
creator: Kuder, Tristan A
creator: Bickelhaupt, Sebastian
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background   Little is known of the influence of scanner field strength on quantitative diffusivity variables, especially kurtosis in healthy ovaries.     Purpose   To evaluate the influence of scanner field strength on quantitative diffusion variables in pelvic MRI of the ovaries.     Material and Methods    This prospective, single-centre study consisted of repeated 1.5-T and 3-T examinations in 30 female volunteers (mean age=27.9 years, age range=20.3–45.2 years) from July 2017 to September 2019. Multi b-value DWI 0, 50, 100, 800, 1500, 2000 s/mm 2 was acquired over three timepoints during the menstrual cycle. Ovaries were segmented at b = 1500 s/mm 2 . Median apparent diffusion coefficient (ADC) and advanced kurtosis parameters D app and K app were calculated. Statistical analysis was performed with the variations of diffusivity variables being compared between 1.5-T and 3-T MRI using a Mann–Whitney rank-sum test.      Results    Median ADC and D app (µm²/ms) did not statistically differ. Median ADC were 1.509 (range=1.371–1.610), 1.619 (range=1.463–1.747), and 1.511 (range=1.423–1.639) at 1.5 T; 1.542 (range=1.428–1.682), 1.658 (range=1.510–1.806), and 1.572 (range=1.455–1.709) at 3 T ( P = 0.14, 0.19, and 0.07), whereas median D app were 2.024 (range=1.913–2.152), 2.192 (range=2.010–2.327), and 2.045 (range=1.958–2.170) at 1.5 T; 2.013 (range=1.952–2.188), 2.179 (range=2.018–2.327), and 2.082 (range=1.959–2.194) at 3 T ( P = 0.77, 0.99, and 0.34) for timepoints 1, 2, and 3, respectively. Statistical comparison of K app revealed significant differences for all timepoints: 0.629 (range=0.595–0.652), 0.604 (range=0.574–0.651), and 0.622 (range=0.581–0.664) at 1.5 T; 0.601 (range=0.563–0.626), 0.567 (range=0.526–0.633), and 0.599 (range=0.541–0.650) at 3 T ( P < 0.001, 0.005, and 0.03).      Conclusion   Diffusivity mapping in the ovaries provides similar absolute median diffusion values, but statistically significant differences in absolute kurtosis values between 1.5 T and 3 T.
publisher: Sage
date: 2025
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/37519/1/10.1177_02841851241313021.pdf
identifier: DOI:10.11588/heidok.00037519
identifier: https://doi.org/10.1177/02841851241313021
identifier: urn:nbn:de:bsz:16-heidok-375199
identifier:   Mokry, Theresa ; Pantke, Judith ; Kauczor, Hans-Ulrich ; Laun, Frederik B ; Schlemmer, Heinz-Peter ; Kuder, Tristan A ; Bickelhaupt, Sebastian  (2025) Influence of field strength on quantitative parameters and feature stability in the assessment of the ovaries using 1.5-T and 3-T MRI.  Acta Radiologica, 66 (5).  pp. 512-520.  ISSN 0284-1851     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/37519/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng