%0 Journal Article
%@ 0284-1851
%A Mokry, Theresa
%A Pantke, Judith
%A Kauczor, Hans-Ulrich
%A Laun, Frederik B
%A Schlemmer, Heinz-Peter
%A Kuder, Tristan A
%A Bickelhaupt, Sebastian
%C London
%D 2025
%F heidok:37519
%I Sage
%J Acta Radiologica
%K Genital, reproductive, magnetic resonance diffusion/perfusion, ovaries, adults
%N 5
%P 512-520
%R 10.11588/heidok.00037519
%T Influence of field strength on quantitative parameters and feature stability in the assessment of the ovaries using 1.5-T and 3-T MRI
%U https://archiv.ub.uni-heidelberg.de/volltextserver/37519/
%V 66
%X Background   Little is known of the influence of scanner field strength on quantitative diffusivity variables, especially kurtosis in healthy ovaries.     Purpose   To evaluate the influence of scanner field strength on quantitative diffusion variables in pelvic MRI of the ovaries.     Material and Methods    This prospective, single-centre study consisted of repeated 1.5-T and 3-T examinations in 30 female volunteers (mean age=27.9 years, age range=20.3–45.2 years) from July 2017 to September 2019. Multi b-value DWI 0, 50, 100, 800, 1500, 2000 s/mm 2 was acquired over three timepoints during the menstrual cycle. Ovaries were segmented at b = 1500 s/mm 2 . Median apparent diffusion coefficient (ADC) and advanced kurtosis parameters D app and K app were calculated. Statistical analysis was performed with the variations of diffusivity variables being compared between 1.5-T and 3-T MRI using a Mann–Whitney rank-sum test.      Results    Median ADC and D app (µm²/ms) did not statistically differ. Median ADC were 1.509 (range=1.371–1.610), 1.619 (range=1.463–1.747), and 1.511 (range=1.423–1.639) at 1.5 T; 1.542 (range=1.428–1.682), 1.658 (range=1.510–1.806), and 1.572 (range=1.455–1.709) at 3 T ( P = 0.14, 0.19, and 0.07), whereas median D app were 2.024 (range=1.913–2.152), 2.192 (range=2.010–2.327), and 2.045 (range=1.958–2.170) at 1.5 T; 2.013 (range=1.952–2.188), 2.179 (range=2.018–2.327), and 2.082 (range=1.959–2.194) at 3 T ( P = 0.77, 0.99, and 0.34) for timepoints 1, 2, and 3, respectively. Statistical comparison of K app revealed significant differences for all timepoints: 0.629 (range=0.595–0.652), 0.604 (range=0.574–0.651), and 0.622 (range=0.581–0.664) at 1.5 T; 0.601 (range=0.563–0.626), 0.567 (range=0.526–0.633), and 0.599 (range=0.541–0.650) at 3 T ( P < 0.001, 0.005, and 0.03).      Conclusion   Diffusivity mapping in the ovaries provides similar absolute median diffusion values, but statistically significant differences in absolute kurtosis values between 1.5 T and 3 T.
%Z Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.