TY  - GEN
N2  - Traditional immunoassays for the detection of specific antibody-antigen  reactions are expensive, time-consuming and non-trivial. In this work,  immunosensors based on surface acoustic wave and electrochemical techniques  are presented, which provide high specificity like conventional immunoassays  and the real-time monitoring of immunoreactions can be achieved. Surface  acoustic wave devices have been widely used in the telecommunication. Besides  their extremely high sensitivity to mass loading they can be utilized for  microbalances. The mass change during an antibody-antigen binding can be  therefore observed by SAW sensors. In this work, ultrasonic waves were  generated on the surface of lithium tantalate by inductively coupled  interdigital transducers to detect antibody-antigen reactions.  The electrical properties at the surface of a sensor are also changed when an antibody-antigen reaction occurs. This can be detected by electrochemical sensors. Capacitively coupled two- and four-electrode sensors were developed  to measure the impedance change at the sensor surface. Effects of the  interaction between electric fields and the electrical double layer near the  liquid-solid interface will also be discussed. Finally, the antibody  affinities can be also measured with both SAW and electrochemical sensors,  indicating a high potential in clinical application.
TI  - Detection of Antibody-Antigen Reactions using Surface Acoustic Wave and Electrochemical Immunosensors
AV  - public
ID  - heidok4787
Y1  - 2004///
A1  - Luo, Cheng-Ping
KW  - Oberflächenwellen 
KW  -  Impedanzsurface acoustic wave 
KW  -  impedance
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/4787/
ER  -