title: Multi-component Reactions Initiated via Sonogashira Coupling
creator: Karpov, Alexei S.
subject: ddc-540
subject: 540 Chemistry and allied sciences
description: It was shown that arylbromides bearing electron-withdrawing groups in appropriate positions can be subjected to Sonogashira coupling with terminal alkynes, producing internal alkynes that can now undergo a Michael addition with suitable secondary amines. This coupling-aminovinylation sequence can be performed in a one-pot fashion, providing a straightforward access to push-pull chromophores.  By applying acid chlorides instead of arylbromides, it was possible to synthesize ynones that are highly reactive and valuable intermediates. Furthermore, we succeeded in directly converting these building blocks into beta-enaminones, pyrimidines and halofurans in a one-pot three-component fashion.
date: 2005
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/5495/1/KarpovPhDThesisfinal.pdf
identifier: DOI:10.11588/heidok.00005495
identifier: urn:nbn:de:bsz:16-opus-54956
identifier:   Karpov, Alexei S.  (2005) Multi-component Reactions Initiated via Sonogashira Coupling.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/5495/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng