<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development"^^ . "Cell motility is essential for many aspects of normal animal development. However, little is known about how cell motility and associated changes in cell shape are regulated in the context of epithelial tissue patterning. This study investigates the cell motility of developing ommatidia, a process known as ommatidial rotation, during Drosophila eye development. The Drosophila eye consists of approximately 800 ommatidia that have to be precisely aligned with respect to one another for proper eye function. This precise alignment is achieved as ommatidia rotate 90° within the plain of the eye imaginal disc epithelium. Only a few mutations have been identified that disrupt this process and the signalling pathways regulating ommatidial rotation remain yet to be revealed. This study characterizes the argosroulette mutation, in which ommatidia rotate to various degrees. Argos is a secreted inhibitor of Spitz, the main activating ligand of the Epidermal growth factor receptor (Egfr). The experiments presented show that modulation of Egfr activity causes defects in ommatidial rotation and implicate the Raf/MAPK/Pointed cascade as well as the Ras binding protein Canoe as downstream effectors of Egfr/Ras in this process. Furthermore, evidence is provided indicating that the regulation of cell adhesion via cadherins is critical for this process. In particular, the atypical cadherin flamingo, a gene known to regulate epithelial planar polarity, appears to play a key role in ommatidial rotation, as its sub-cellular localisation is disturbed in argosroulette mutants. Genetic interactions further implicate non-muscle Myosin II as well as genes involved in actin polymerisation/depolymerisation in this process. This study also describes the design of an F1 screen intended to identify new genes involved in ommatidial rotation. Preliminary results obtained in a pilot screen identified the Drosophila PDGF/VEGF receptor orthologue (PVR) as a candidate. The requirement of Egfr and a potential role for PVR in ommatidial rotation are intriguing, as they suggest a remarkable parallel to border cell migration, where partially redundant functions of these signalling pathways have recently been reported. Thus, the regulation of cell motility in Drosophila might be controlled through similar pathways and mechanisms in different cellular contexts. "^^ . "2005" . . . . . . . . "Konstantin"^^ . "Gängel"^^ . "Konstantin Gängel"^^ . . . . . . "Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development (PDF)"^^ . . . "PhD.pdf"^^ . . . "Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #5666 \n\nEpidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .