%0 Journal Article
%A Wolf, Markus
%A Bauder-Wüst, Ulrike
%A Pipkorn, Rüdiger
%D 2006
%F heidok:6214
%K MRI , contrats agent, guanidinium , PreS2TML
%R 10.11588/heidok.00006214
%T PreS2-TML peptide or guanidinium modified Gd-DOTA exhibits efficient cellular uptake
%U https://archiv.ub.uni-heidelberg.de/volltextserver/6214/
%X The majority of magnetic resonance contrast agents are restricted to the extracellular domains. For  the development of novel, intracellular magnetic resonance contrast agents, we have designed Gd-DOTA derivatives comprising  PreS2-TML peptide or ethylguanidinium as carrier  moiety. Initial in vitro cell uptake studies with Jurkat cells revealed efficient contrast agent uptake for imaging purposes, in the range of 0.04 fmol/cell (PreS2-TML peptide) to 0.2 fmol/cell (ethylguanidinium) following 2 h incubations at 100 µM.