TY  - JOUR
ID  - heidok6214
Y1  - 2006///
TI  - PreS2-TML peptide or guanidinium modified Gd-DOTA exhibits efficient cellular uptake
KW  - MRI 
KW  -  contrats agent
KW  -  guanidinium 
KW  -  PreS2TML
AV  - public
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/6214/
A1  - Wolf, Markus
A1  - Bauder-Wüst, Ulrike
A1  - Pipkorn, Rüdiger
N2  - The majority of magnetic resonance contrast agents are restricted to the extracellular domains. For  the development of novel, intracellular magnetic resonance contrast agents, we have designed Gd-DOTA derivatives comprising  PreS2-TML peptide or ethylguanidinium as carrier  moiety. Initial in vitro cell uptake studies with Jurkat cells revealed efficient contrast agent uptake for imaging purposes, in the range of 0.04 fmol/cell (PreS2-TML peptide) to 0.2 fmol/cell (ethylguanidinium) following 2 h incubations at 100 µM.
ER  -