eprintid: 6214
rev_number: 16
eprint_status: archive
userid: 1
dir: disk0/00/00/62/14
datestamp: 2006-03-23 14:54:37
lastmod: 2016-01-20 21:30:14
status_changed: 2012-08-14 15:17:37
type: article
metadata_visibility: show
creators_name: Wolf, Markus
creators_name: Bauder-Wüst, Ulrike
creators_name: Pipkorn, Rüdiger
title: PreS2-TML peptide or guanidinium modified Gd-DOTA exhibits efficient cellular uptake
ispublished: pub
subjects: ddc-610
divisions: i-850300
keywords: MRI , contrats agent, guanidinium , PreS2TML
cterms_swd: NMR-Bildgebung
cterms_swd: Kontrastmittel
abstract: The majority of magnetic resonance contrast agents are restricted to the extracellular domains. For  the development of novel, intracellular magnetic resonance contrast agents, we have designed Gd-DOTA derivatives comprising  PreS2-TML peptide or ethylguanidinium as carrier  moiety. Initial in vitro cell uptake studies with Jurkat cells revealed efficient contrast agent uptake for imaging purposes, in the range of 0.04 fmol/cell (PreS2-TML peptide) to 0.2 fmol/cell (ethylguanidinium) following 2 h incubations at 100 µM.
abstract_translated_lang: eng
date: 2006
date_type: published
id_scheme: DOI
id_number: 10.11588/heidok.00006214
ppn_swb: -
own_urn: urn:nbn:de:bsz:16-opus-62140
language: eng
bibsort: WOLFMARKUSPRES2TMLPE2006
full_text_status: public
citation:   Wolf, Markus ; Bauder-Wüst, Ulrike ; Pipkorn, Rüdiger  (2006) PreS2-TML peptide or guanidinium modified Gd-DOTA exhibits efficient cellular uptake.         
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/6214/1/wolf.pdf