<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Forces Are Able to Set Position And Timing Of Microtubule Catastrophes In Fission Yeast"^^ . "In the fission yeast Schizosaccharomyces pombe, interphase microtubules switch to depolymerization almost exclusively at the poles of the cylindrical cell. Proper localization of these events is crucial for morphogenesis, and is thought to depend on factors preferentially localized at the cell poles. Using computer simulations we analyzed five different models of how microtubule dynamic instability might be regulated in order to reproduce the organization of microtubules observed in vivo. To evaluate the simulations we compared their output to nine traits of interphase cells. Using the simulation we could show that the shape of fission yeast induces forces on microtubule plus ends specifically at the cell poles. We found that the effect of these forces on microtubule dynamics was sufficient to reproduce the nine traits without the requirement of pole-specific factors. In vivo experiments with mutant cells confirmed that cell shape is essential for the proper organization of microtubules in fission yeast which indicates that force might also be relevant in living cells. We furthermore applied the simulation to study the organization of microtubules in mutant cells that were deleted of the microtubule tip tracking proteins Mal3 and Tip1. This lead to the proposal of a novel hypothesis how Tip1 might function in vivo to assist force in the discrimination of the cell poles from central parts of the cell cortex."^^ . "2007" . . . . . . . . "Dietrich"^^ . "Foethke"^^ . "Dietrich Foethke"^^ . . . . . . "Forces Are Able to Set Position And Timing Of Microtubule Catastrophes In Fission Yeast (PDF)"^^ . . . "phd_thesis_dietrich_foethke_300dpi.pdf"^^ . . . "Forces Are Able to Set Position And Timing Of Microtubule Catastrophes In Fission Yeast (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Forces Are Able to Set Position And Timing Of Microtubule Catastrophes In Fission Yeast (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Forces Are Able to Set Position And Timing Of Microtubule Catastrophes In Fission Yeast (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Forces Are Able to Set Position And Timing Of Microtubule Catastrophes In Fission Yeast (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Forces Are Able to Set Position And Timing Of Microtubule Catastrophes In Fission Yeast (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #7312 \n\nForces Are Able to Set Position And Timing Of Microtubule Catastrophes In Fission Yeast\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .