TY  - GEN
KW  - Zerstauebung 
KW  -  Cyclodextrin 
KW  -  Cyclosporin 
KW  -  LungenübergabeNebulisation 
KW  -  Cyclodextrin 
KW  -  Cyclosporin 
KW  -  Pulmonary
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/7638/
Y1  - 2006///
ID  - heidok7638
AV  - public
N2  - In this work, we investigated the solubility enhancement of 3 water insoluble drugs by using cyclodextrins in two pharmaceutical delivery forms: Solutions and Suspensions. A preliminary conclusion was that through the use of cyclodextrins it was possible to increase the solubility of the 3 water insoluble drugs, Cyclosporin A, Azithromycin and Budesonide. In addition,all the formulations were stable and suitable to be nebulised using the intended eflow device.It was also an objective of this work the elaboration of a systematic pathway for the development of formulations suitable for nebulisation. Based on the knowledge collect during this work, a database system was built as an aid tool for the pharmaceutical formulation development process. In conclusion, it was able to increase the solubility/stability and also to taste mask formulations containing both water insoluble and water soluble drugs. This opens new possibilities to the pulmonary delivery as an alternative non-invasive method of delivering drugs that currently can only be delivered orally or intravenously.
TI  - SYSTEMATIC DEVELOPMENT OF FORMULATIONS SUITABLE FOR PULMONARY APPLICATIONS BY NEBULISATION
A1  - Raposo, Antonio
ER  -