<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Impaired representation of space in the hippocampus of GluR-A knockout mice"^^ . "To investigate the role of AMPAR-mediated synaptic transmission in the placespecific firing of the hippocampal CA1 pyramidal cells, we have applied multiple tetrode recording techniques in freely behaving mice with a complete knockout of the GluR-A gene. We have found that place-specific activity of the neurons was significantly impaired in the GluR-A KO mice. The pyramidal cells in GluR-A KO mice formed firing (place)fields, that were: significantly larger (160-200%), less location selective (73%), less direction selective (39%), less stable (53%) and carried less information about the animal’s position (47%) than those cells studied in wild-type mice. Despite the observed positive correlation between the firing field’s properties and the degree of cognitive demands of three employed behavioral paradigms, the spatial firing defects were consistent across the paradigms independent from their complexity. We have also found that deletion of the GluR-A gene slightly reduced (5%) the frequency of the hippocampal theta rhythm, but did not affect relative timing of the pyramidal cell spikes in respect to the theta rhythm. These results demonstrate that GluR-A-containing AMPA receptors are necessary for the normal representation of space in the CA1 region of the hippocampus, which might be necessary for the flexible working memory system."^^ . "2007" . . . . . . . . "Evgeny"^^ . "Resnik"^^ . "Evgeny Resnik"^^ . . . . . . "Impaired representation of space in the hippocampus of GluR-A knockout mice (PDF)"^^ . . . "PhD_thesis_Evgeny_Resnik_MPIMF.pdf"^^ . . . "Impaired representation of space in the hippocampus of GluR-A knockout mice (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Impaired representation of space in the hippocampus of GluR-A knockout mice (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Impaired representation of space in the hippocampus of GluR-A knockout mice (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Impaired representation of space in the hippocampus of GluR-A knockout mice (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Impaired representation of space in the hippocampus of GluR-A knockout mice (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #8083 \n\nImpaired representation of space in the hippocampus of GluR-A knockout mice\n\n" . "text/html" . . . "530 Physik"@de . "530 Physics"@en . .