eprintid: 8350
rev_number: 8
eprint_status: archive
userid: 1
dir: disk0/00/00/83/50
datestamp: 2008-04-15 13:44:45
lastmod: 2014-08-18 22:52:12
status_changed: 2012-08-14 15:25:10
type: article
metadata_visibility: show
creators_name: Kvist, S.
creators_name: Roberts, L .
creators_name: Dobberstein, Bernhard
title: Mouse histocompatibility genes: structure and organisation of a Kd gene
ispublished: pub
subjects: ddc-570
divisions: i-706000
keywords: alternative splicing , gene conversion , K locus genes , nucleotide sequence
abstract: The gene coding for the mouse H-2Kd antigen has been isolated by using a K-locus specific cDNA probe. The complete nucleotide sequence of the gene reveals eight exons separated by seven introns. Transcriptionally important DNA sequences (CCAAT and TATA) precede the first exon. Comparison with other H-2 genes shows extensive homology in exons as well as in introns. Two cDNA clones encoding Kd antigens have been analysed and provide evidence for at least two expressed Kd genes in the DBA/2 mouse. Comparison of the Kd antigen sequence to three other H-2 antigens indicates that gene conversion mechanism(s) act on H-2 genes. Analyses of exon donor and acceptor sites of different H-2 genes and cDNAs show that alternative splicing sites are used by different genes. 
abstract_translated_lang: eng
date: 1983
date_type: published
id_scheme: DOI
id_number: 10.11588/heidok.00008350
schriftenreihe_cluster_id: sr-2
schriftenreihe_order: 026
ppn_swb: 1349156930
own_urn: urn:nbn:de:bsz:16-opus-83506
language: ger
bibsort: KVISTSMOUSEHISTO1983
full_text_status: public
publication: The EMBO Journal
volume: 2
number: 2
pagerange: 245-254
citation:   Kvist, S. ; Roberts, L . ; Dobberstein, Bernhard  (1983) Mouse histocompatibility genes: structure and organisation of a Kd gene.  The EMBO Journal, 2 (2).  pp. 245-254.      
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/8350/1/Kvist_1983_EMBOJ.pdf