title: The Protein-Conducting Channel in the Membrane of the Endoplasmic Reticulum Is Open Laterally toward the Lipid Bilayer
creator: Martoglio, Bruno
creator: Hofmann, Michael W.
creator: Brunner, Josef
creator: Dobberstein, Bernhard
subject: 570
subject: 570 Life sciences
description: Lipids and proteins were found to contact a nascent type II membrane protein, as well as a nascent secretory protein, during their insertion into the membrane of the endoplasmic reticulum. This suggests that the protein-conducting channel is open laterally toward the lipid bilayer during an early stage of protein insertion. Contact to lipids was confined to the hydrophobic core region of the respective signal or signal anchor sequence. Thus, the nascent polypeptide is positioned in the translocation complex such that the signal or signal anchor sequence faces the lipid bilayer, whereas the hydrophilic, translocating portion is in proteinaceous environment.
date: 1995
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/8379/1/Martoglio_1995_Cell.pdf
identifier: DOI:10.11588/heidok.00008379
identifier: urn:nbn:de:bsz:16-opus-83793
identifier:   Martoglio, Bruno ; Hofmann, Michael W. ; Brunner, Josef ; Dobberstein, Bernhard  (1995) The Protein-Conducting Channel in the Membrane of the Endoplasmic Reticulum Is Open Laterally toward the Lipid Bilayer.  Cell, 81.  pp. 207-214.      
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/8379/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng