TY  - JOUR
SP  - 207
TI  - The Protein-Conducting Channel in the Membrane of the Endoplasmic Reticulum Is Open Laterally toward the Lipid Bilayer
ID  - heidok8379
AV  - public
JF  - Cell
VL  - 81
EP  - 214
Y1  - 1995///
A1  - Martoglio, Bruno
A1  - Hofmann, Michael W.
A1  - Brunner, Josef
A1  - Dobberstein, Bernhard
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/8379/
N2  - Lipids and proteins were found to contact a nascent type II membrane protein, as well as a nascent secretory protein, during their insertion into the membrane of the endoplasmic reticulum. This suggests that the protein-conducting channel is open laterally toward the lipid bilayer during an early stage of protein insertion. Contact to lipids was confined to the hydrophobic core region of the respective signal or signal anchor sequence. Thus, the nascent polypeptide is positioned in the translocation complex such that the signal or signal anchor sequence faces the lipid bilayer, whereas the hydrophilic, translocating portion is in proteinaceous environment.
ER  -