eprintid: 8379
rev_number: 8
eprint_status: archive
userid: 1
dir: disk0/00/00/83/79
datestamp: 2008-04-30 17:28:16
lastmod: 2014-09-04 01:24:20
status_changed: 2012-08-14 15:25:17
type: article
metadata_visibility: show
creators_name: Martoglio, Bruno
creators_name: Hofmann, Michael W.
creators_name: Brunner, Josef
creators_name: Dobberstein, Bernhard
title: The Protein-Conducting Channel in the Membrane of the Endoplasmic Reticulum Is Open Laterally toward the Lipid Bilayer
ispublished: pub
subjects: 570
divisions: 706000
abstract: Lipids and proteins were found to contact a nascent type II membrane protein, as well as a nascent secretory protein, during their insertion into the membrane of the endoplasmic reticulum. This suggests that the protein-conducting channel is open laterally toward the lipid bilayer during an early stage of protein insertion. Contact to lipids was confined to the hydrophobic core region of the respective signal or signal anchor sequence. Thus, the nascent polypeptide is positioned in the translocation complex such that the signal or signal anchor sequence faces the lipid bilayer, whereas the hydrophilic, translocating portion is in proteinaceous environment.
abstract_translated_lang: eng
date: 1995
date_type: published
id_scheme: DOI
id_number: 10.11588/heidok.00008379
schriftenreihe_cluster_id: sr-2
schriftenreihe_order: 078
ppn_swb: 1349722936
own_urn: urn:nbn:de:bsz:16-opus-83793
language: eng
bibsort: MARTOGLIOBTHEPROTEIN1995
full_text_status: public
publication: Cell
volume: 81
pagerange: 207-214
citation:   Martoglio, Bruno ; Hofmann, Michael W. ; Brunner, Josef ; Dobberstein, Bernhard  (1995) The Protein-Conducting Channel in the Membrane of the Endoplasmic Reticulum Is Open Laterally toward the Lipid Bilayer.  Cell, 81.  pp. 207-214.      
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/8379/1/Martoglio_1995_Cell.pdf