<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins"^^ . "Translocation of proteins across the endoplasmic reticulum membrane is initiated by the signal recognition particle (SRP), a cytoplasmic ribonucleoprotein complex consisting of a 7S RNA and six polypeptides. To investigate the functions of the SRP components, we have tested the activities of several SRP subparticles. We show that the SRP GTPase (SRP54) alone binds a signal sequence and discriminates it from a non-signal sequence. Although SRP54 alone is unable to promote translocation, SRP54 in a complex with SRP RNA is both necessary and sufficient to promote translocation of an elongation-arrested nascent protein in a GTPregulated manner. For co-translational translocation, additional SRP components are required. We discuss the implications of our results for the function of the Escherichia coli SRP which is homologous to the SRP54/SRP-RNA complex. "^^ . "1995" . . . "14" . "22" . . "The EMBO Journal"^^ . . . . . . . . . . . . . . . . "Gerald"^^ . "Bacher"^^ . "Gerald Bacher"^^ . . "Henrich"^^ . "Lütcke"^^ . "Henrich Lütcke"^^ . . "Stefanie"^^ . "Hauser"^^ . "Stefanie Hauser"^^ . . "Bernhard"^^ . "Dobberstein"^^ . "Bernhard Dobberstein"^^ . . . . . . "A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins (PDF)"^^ . . . "Hauser_1995_EMBOJ.pdf"^^ . . . "A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins (Other)"^^ . . . . . . "preview.jpg"^^ . . . "A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins (Other)"^^ . . . . . . "medium.jpg"^^ . . . "A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #8478 \n\nA complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .