%0 Journal Article
%A Koch, Norbert
%A Lauer, Wolfgang
%A Habicht, Jüri
%A Dobberstein, Bernhard
%D 1987
%F heidok:8479
%J The EMBO Journal
%K invariant chain gene, class II histocompatibility antigens , alternative-splicing , hyroglobulin , antigen processing
%N 6
%P 1677-1683
%R 10.11588/heidok.00008479
%T Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin
%U https://archiv.ub.uni-heidelberg.de/volltextserver/8479/
%V 6
%X The gene for murine Ia-associated invariant (1i) chains (1131 and 1i41) was characterized by sequence analysis. The gene extends over - 9 kb and is organized in nine exons. Exon 1 encodes the 5' untranslated region and the cytoplasmic segment, exon 2 the membrane spaniing segment and adjacent amino acids and exons 3- 8 the extracytoplasmic portion of 1131. Putative promoter sequences were found upstream of the start of the coding sequence. Between exons 6 and 7 an additional, alternatively spliced exon 6b has been identified. This exon is spliced into the mRNA coding for the li-related Ii41 protein. Exon 6b encodes a cysteine-rich domain of 64 amino acids. It shows a remarkably high homology to the repetitive elements in thyroglobulin, a precursor for thyroid hormone. Based on this homology, it is suggested that this domain (TgR) in Tg and in 1141 may play a role either in hormone formation or as a carrier in the transport of molecules (thyroid hormone or processed antigen respectively) between intracellular compartments.