<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin"^^ . "The gene for murine Ia-associated invariant (1i) chains (1131 and 1i41) was characterized by sequence analysis. The gene extends over - 9 kb and is organized in nine exons. Exon 1 encodes the 5' untranslated region and the cytoplasmic segment, exon 2 the membrane spaniing segment and adjacent amino acids and exons 3- 8 the extracytoplasmic portion of 1131. Putative promoter sequences were found upstream of the start of the coding sequence. Between exons 6 and 7 an additional, alternatively spliced exon 6b has been identified. This exon is spliced into the mRNA coding for the li-related Ii41 protein. Exon 6b encodes a cysteine-rich domain of 64 amino acids. It shows a remarkably high homology to the repetitive elements in thyroglobulin, a precursor for thyroid hormone. Based on this homology, it is suggested that this domain (TgR) in Tg and in 1141 may play a role either in hormone formation or as a carrier in the transport of molecules (thyroid hormone or processed antigen respectively) between intracellular compartments. "^^ . "1987" . . . "6" . "6" . . "The EMBO Journal"^^ . . . . . . . . . . . . . . . . "Jüri"^^ . "Habicht"^^ . "Jüri Habicht"^^ . . "Wolfgang"^^ . "Lauer"^^ . "Wolfgang Lauer"^^ . . "Bernhard"^^ . "Dobberstein"^^ . "Bernhard Dobberstein"^^ . . "Norbert"^^ . "Koch"^^ . "Norbert Koch"^^ . . . . . . "Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin (PDF)"^^ . . . "Koch_1987_EMBOJ.pdf"^^ . . . "Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #8479 \n\nPrimary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .