TY  - JOUR
IS  - 6
VL  - 6
SP  - 1677
EP  - 1683
N2  - The gene for murine Ia-associated invariant (1i) chains (1131 and 1i41) was characterized by sequence analysis. The gene extends over - 9 kb and is organized in nine exons. Exon 1 encodes the 5' untranslated region and the cytoplasmic segment, exon 2 the membrane spaniing segment and adjacent amino acids and exons 3- 8 the extracytoplasmic portion of 1131. Putative promoter sequences were found upstream of the start of the coding sequence. Between exons 6 and 7 an additional, alternatively spliced exon 6b has been identified. This exon is spliced into the mRNA coding for the li-related Ii41 protein. Exon 6b encodes a cysteine-rich domain of 64 amino acids. It shows a remarkably high homology to the repetitive elements in thyroglobulin, a precursor for thyroid hormone. Based on this homology, it is suggested that this domain (TgR) in Tg and in 1141 may play a role either in hormone formation or as a carrier in the transport of molecules (thyroid hormone or processed antigen respectively) between intracellular compartments. 
A1  - Koch, Norbert
A1  - Lauer, Wolfgang
A1  - Habicht, Jüri
A1  - Dobberstein, Bernhard
JF  - The EMBO Journal
ID  - heidok8479
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/8479/
KW  - invariant chain gene
KW  -  class II histocompatibility antigens 
KW  -  alternative-splicing 
KW  -  hyroglobulin 
KW  -  antigen processing
Y1  - 1987///
TI  - Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin
AV  - public
ER  -