eprintid: 8479
rev_number: 24
eprint_status: archive
userid: 1
dir: disk0/00/00/84/79
datestamp: 2008-06-17 17:33:35
lastmod: 2016-01-15 09:53:29
status_changed: 2012-08-14 15:25:37
type: article
metadata_visibility: show
creators_name: Koch, Norbert
creators_name: Lauer, Wolfgang
creators_name: Habicht, Jüri
creators_name: Dobberstein, Bernhard
title: Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin
ispublished: pub
subjects: ddc-570
divisions: i-706000
keywords: invariant chain gene, class II histocompatibility antigens , alternative-splicing , hyroglobulin , antigen processing
abstract: The gene for murine Ia-associated invariant (1i) chains (1131 and 1i41) was characterized by sequence analysis. The gene extends over - 9 kb and is organized in nine exons. Exon 1 encodes the 5' untranslated region and the cytoplasmic segment, exon 2 the membrane spaniing segment and adjacent amino acids and exons 3- 8 the extracytoplasmic portion of 1131. Putative promoter sequences were found upstream of the start of the coding sequence. Between exons 6 and 7 an additional, alternatively spliced exon 6b has been identified. This exon is spliced into the mRNA coding for the li-related Ii41 protein. Exon 6b encodes a cysteine-rich domain of 64 amino acids. It shows a remarkably high homology to the repetitive elements in thyroglobulin, a precursor for thyroid hormone. Based on this homology, it is suggested that this domain (TgR) in Tg and in 1141 may play a role either in hormone formation or as a carrier in the transport of molecules (thyroid hormone or processed antigen respectively) between intracellular compartments. 
abstract_translated_lang: eng
date: 1987
date_type: published
id_scheme: DOI
id_number: 10.11588/heidok.00008479
schriftenreihe_cluster_id: sr-2
schriftenreihe_order: 037
ppn_swb: 1352587823
own_urn: urn:nbn:de:bsz:16-opus-84799
language: eng
bibsort: KOCHNORBERPRIMARYSTR1987
full_text_status: public
publication: The EMBO Journal
volume: 6
number: 6
pagerange: 1677-1683
citation:   Koch, Norbert ; Lauer, Wolfgang ; Habicht, Jüri ; Dobberstein, Bernhard  (1987) Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin.  The EMBO Journal, 6 (6).  pp. 1677-1683.      
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/8479/1/Koch_1987_EMBOJ.pdf