<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Assembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA"^^ . "Signal recognition particle (SRP), the cytoplasmic ribonucleoprotein particle that mediates the targeting of proteins to the ER, consists of a 7S RNA and six different proteins. The 68- (SRP68) and 72-(SRP72) kD proteins of SRP are bound to the 7S RNA of SRP as a heterodimeric complex (SRP68/72). Here we describe the primary structure of SRP72 and the assembly of SRP68, SRP72 and 7S RNA into a ribonucleoprotein particle. The amino acid sequence deduced from the cDNA of SRP72 reveals a basic protein of 671 amino acids which shares no sequence similarity with any protein in the sequence data libraries. Assembly of SRP72 into a ribonucleoprotein particle required the presence of 7S RNA and SRP68. In contrast, SRP68 alone specifically bound to 7S RNA. SRP68 contacts the 7S RNA via its NH2-terminal half while COOH-terminal portions of SRP68 and SRP72 are in contact with each other in SRP. SRP68 thus serves as a link between 7S RNA and SRP72. As a large NH2-terminal domain of SRP72 is exposed on SRP it may be a site of contact to other molecules involved in the SRP cycle between the ribosome and the ER membrane."^^ . "1993" . . . "121" . "5" . . "The Journal of Cell Biology"^^ . . . . . . . . . . . . . . . . . . . . . . "Henrich"^^ . "Lütcke"^^ . "Henrich Lütcke"^^ . . "Michael"^^ . "Remus"^^ . "Michael Remus"^^ . . "Bernhard"^^ . "Dobberstein"^^ . "Bernhard Dobberstein"^^ . . "Anthony J."^^ . "Ashford"^^ . "Anthony J. Ashford"^^ . . "Siegfried"^^ . "Prehn"^^ . "Siegfried Prehn"^^ . . "Rainer"^^ . "Frank"^^ . "Rainer Frank"^^ . . . . . . "Assembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA (PDF)"^^ . . . "Luetcke_1993_JCB.pdf"^^ . . . "Assembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Assembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Assembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Assembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Assembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #8581 \n\nAssembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .