%0 Generic
%A Addali, Ayoub
%D 2024
%F heidok:34535
%K Orthopädie
%T klinisches Outcome bei der Behandlung von Pseudarthrose nach dem „Diamond-Konzept“
%U https://archiv.ub.uni-heidelberg.de/volltextserver/34535/

%0 Generic
%A Bock, Tobias
%D 2024
%F heidok:34547
%K Chirurgie
%T Die frühe operative Versorgung der akuten traumatischen Rückenmarksverletzung
%U https://archiv.ub.uni-heidelberg.de/volltextserver/34547/

%0 Generic
%A Decker, Simon Johannes
%D 2024
%F heidok:34661
%K Orthopädie
%T Evaluation der Zytokompatibilität sowie des osteogenen und angiogenen Potentials ionischer Zersetzungsprodukte Bor-supplementierter bioaktiver Gläser in vitro und in ovo
%U https://archiv.ub.uni-heidelberg.de/volltextserver/34661/

%0 Generic
%A Essers, Christopher
%D 2024
%F heidok:34658
%K Orthopädie
%T Untersuchung der osteostimulativen Eigenschaften von Vitoss® im Vergleich zu Vitoss® BA in-vivo
%U https://archiv.ub.uni-heidelberg.de/volltextserver/34658/

%0 Generic
%A Reiner, Christian
%D 2024
%F heidok:34544
%K Orthopädie
%T Verursacht die Applikation von BMP-7 zur Therapie von Pseudarthrosen langer Röhrenknochen eine pathologische Zytokinexpression von IGF-1, PDGF-AB und TGF-ß?
%U https://archiv.ub.uni-heidelberg.de/volltextserver/34544/

%0 Generic
%A Heller, Raban
%D 2023
%F heidok:33498
%K Orthopädie
%T Prädiktion des neurologischen Remissionspotentials nach traumatischer Rückenmarksverletzung
%U https://archiv.ub.uni-heidelberg.de/volltextserver/33498/

%0 Generic
%A Banken, Lukas
%D 2022
%F heidok:31749
%K Orthopädie
%T Ergebnisse nach mehrfragmentärer Radiuskopffraktur : Plattenosteosynthese vs. Endoprothese
%U https://archiv.ub.uni-heidelberg.de/volltextserver/31749/

%0 Generic
%A Schönewald, Marius
%D 2022
%F heidok:32600
%K Orthopädie
%T Ein klinischer Vergleich der MoPyC®-Prothesenimplantation mit der Verwendung von winkelstabilen Implantaten bei der operativen Primärversorgung von traumatischen mehrfragmentären Radiuskopffrakturen
%U https://archiv.ub.uni-heidelberg.de/volltextserver/32600/

%0 Generic
%A Widholz, Benedikt
%D 2022
%F heidok:32960
%K Orthopädie
%T Evaluation der osteogenen Eigenschaften des bioaktiven Borosilikatglases 0106-B1 in-vitro und in-vivo
%U https://archiv.ub.uni-heidelberg.de/volltextserver/32960/

%0 Generic
%A Schmitz, Sarah Isabelle
%D 2021
%F heidok:31232
%K Orthopädie
%T Überlegene Bioverträglichkeit bei vergleichbaren osteogenen Eigenschaften : Natriumreduzierte Fluorid-enthaltende bioaktive Gläser aus dem CaO–MgO–SiO2-System als vielversprechende Alternative zu 45S5 bioaktivem Glas
%U https://archiv.ub.uni-heidelberg.de/volltextserver/31232/

%0 Generic
%A Sperl, Andre
%D 2021
%F heidok:30665
%K Orthopädie
%T Das neuroprotektive Potential von IGF-1 analysiert an Patienten nach traumatischer Rückenmarksverletzung
%U https://archiv.ub.uni-heidelberg.de/volltextserver/30665/

%0 Generic
%A Thönnes, Simon
%D 2020
%F heidok:28204
%K Orthopädie
%T Optimierung eines Sehnen- und Bandxenografts basierend auf einem aviären Sehnenscaffold
%U https://archiv.ub.uni-heidelberg.de/volltextserver/28204/

%0 Generic
%A Weis, Johanna Sophia
%D 2019
%F heidok:26591
%K Orthopädie
%T Klinische Ergebnisse der Anwendung von ETN PROtect® in der Behandlung von Pseudarthrosen
%U https://archiv.ub.uni-heidelberg.de/volltextserver/26591/

%0 Journal Article
%@ 1749-799X
%A Haubruck, Patrick
%A Solte, Anja
%A Heller, Raban
%A Daniel, Volker
%A Tanner, Michael
%A Moghaddam, Arash
%A Schmidmaier, Gerhard
%A Fischer, Christian
%C London
%D 2018
%F heidok:25479
%I BioMed Central
%J Journal of Orthopaedic Surgery and Research
%N 249
%P 1-11
%T Chemokine analysis as a novel diagnostic modality in the early prediction of the outcome of non-union therapy: a matched pair analysis
%U https://archiv.ub.uni-heidelberg.de/volltextserver/25479/
%V 13
%X Background: Despite the regenerative capability of skeletal tissue fracture, non-union is common. Treatment of non-unions remains challenging, and early determination of the outcome is impossible. Chemokines play an important role in promoting the formation of new bone and remodeling existing bone. Despite their importance regarding the regulation of bone biology, the potential of chemokines as biological markers reflecting osseous regeneration is unknown. The purpose of this study was to determine (1) if serum chemokine expression levels correlate with the outcome of non-union surgery and (2) if chemokine expression analysis can be used to identify patients at risk for treatment failure.    Methods: Non-union patients receiving surgical therapy in our institution between March 2012 and March 2014 were prospectively enrolled in a clinical observer study. Regular clinical and radiological follow-up was conducted for 12 months including collection of blood during the first 12 weeks. Based on the outcome, patients were declared as responders or non-responders to the therapy. To minimize biases, patients were matched (age, sex, body mass index (BMI)) and two groups of patients could be formed: responders (R, n = 10) and non-responders (NR, n = 10). Serum chemokine expression (CCL-2, CCL-3, CCL-4, CXCL-10, CCL-11, and interferon gamma (IFN-γ)) was analyzed using Luminex assays. Data was compared and correlated to the outcome.    Results: CCL-3 expression in NR was significantly higher during the course of the study compared to R (p = 0.002), and the expression pattern of CCL-4 correlated with CCL-3 in both groups (NR: p < 0.001 and r = 0.63). IFN-γ expression in NR was continuously higher than in R (p < 0.001), and utilization of CCL-3 and IFN-γ serum expression levels 2 weeks after the treatment resulted in a predictive model that had an AUC of 0.92 (CI 0.74–1.00).    Conclusion: Serum chemokine expression analysis over time is a valid and promising diagnostic tool. The chemokine expression pattern correlates with the outcome of the Masquelet therapy of lower limb non-unions. Utilization of the serum analysis of CCL-3 and IFN-γ 2 weeks after the treatment resulted in an early predictive value regarding the differentiation between patients that are likely to heal and those that are prone to high risk of treatment failure.

%0 Journal Article
%@ 1471-2474
%A Helbig, Lars
%A Omlor, Georg W.
%A Ivanova, Adriana
%A Guehring, Thorsten
%A Sonntag, Robert
%A Kretzer, J. Philippe
%A Minkwitz, Susann
%A Wildemann, Britt
%A Schmidmaier, Gerhard
%C London
%D 2018
%F heidok:25168
%I BioMed Central
%J BMC Musculoskeletal Disorders
%N 261
%P 1-13
%T Bone morphogenetic proteins − 7 and − 2 in the treatment of delayed osseous union secondary to bacterial osteitis in a rat model
%U https://archiv.ub.uni-heidelberg.de/volltextserver/25168/
%V 19
%X Background: Bone infections due to trauma and subsequent delayed or impaired fracture healing represent a great challenge in orthopedics and trauma surgery. The prevalence of such bacterial infection-related types of delayed non-union is high in complex fractures, particularly in open fractures with additional extensive soft-tissue damage. The aim of this study was to establish a rat model of delayed osseous union secondary to bacterial osteitis and investigate the impact of rhBMP-7 and rhBMP-2 on fracture healing in the situation of an ongoing infection.    Methods: After randomization to four groups 72 Sprague-Dawley rats underwent a transverse fracture of the midshaft tibia stabilized by intramedullary titanium K-wires. Three groups received an intramedullary inoculation with Staphylococcus aureus (103 colony-forming units) before stabilization and the group without bacteria inoculation served as healing control. After 5 weeks, a second surgery was performed with irrigation of the medullary canal and local rhBMP-7 and rhBMP-2 treatment whereas control group and infected control group received sterile saline. After further 5 weeks rats were sacrificed and underwent biomechanical testing to assess the mechanical stability of the fractured bone. Additional micro-CT analysis, histological, and histomorphometric analysis were done to evaluate bone consolidation or delayed union, respectively, and to quantify callus formation and the mineralized area of the callus.       Results: Biomechanical testing showed a significantly higher fracture torque in the non-infected control group and the infected rhBMP-7- and rhBMP-2 group compared with the infected control group (p < 0.001). RhBMP-7 and rhBMP-2 groups did not show statistically significant differences (p = 0.57). Histological findings supported improved bone-healing after rhBMP treatment but quantitative micro-CT and histomorphometric results still showed significantly more hypertrophic callus tissue in all three infected groups compared to the non-infected group. Results from a semiquantitative bone-healing-score revealed best bone-healing in the non-infected control group. The expected chronic infection was confirmed in all infected groups.    Conclusions: In delayed bone healing secondary to infection rhBMP treatment promotes bone healing with no significant differences in the healing efficacy of rhBMP-2 and rhBMP-7 being noted. Further new therapeutic bone substitutes should be analyzed with the present rat model for delayed osseous union secondary to bacterial osteitis.

%0 Generic
%A Kammerer, Andreas
%D 2018
%F heidok:25820
%K Orthopädie
%T Evaluation des Einflusses der lokalen Applikation von Bone morphogenetic protein 7 auf die Angiogenese und Inflammation in der Pseudarthrosentherapie anhand von serologischer Zytokinexpressionsanalyse.
%U https://archiv.ub.uni-heidelberg.de/volltextserver/25820/

%0 Generic
%A Prokscha, Matthäus Markus
%D 2018
%F heidok:26043
%K Orthopädie
%T Das osteogene Potential von humanen mesenchymalen Stammzellen unterschiedlicher Herkunftsgewebe und verschiedener Knochenersatzstoffe im Rahmen des Knochen Tissue Engineerings
%U https://archiv.ub.uni-heidelberg.de/volltextserver/26043/

%0 Generic
%A Seeböck-Göbel, Thomas
%D 2018
%F heidok:24381
%K Orthopädie
%T Funktionelles und psychosoziales Outcome nach hüftgelenksnahen Frakturen  Welchen Einfluss hat die Akutgeriatrische Behandlung?
%U https://archiv.ub.uni-heidelberg.de/volltextserver/24381/

%0 Generic
%A Apitz, Philipp Alexander
%D 2017
%F heidok:23474
%K Orthopädie
%T Evaluation des Einflusses der Inflammationsreaktion und der Angiogenese auf das Outcome der Masquelet-Therapie anhand des Expressionsmusters der proinflammatorischen Zytokine IL-6, IL-8, TNF-alpha und des Angiogenesefaktors VEGF
%U https://archiv.ub.uni-heidelberg.de/volltextserver/23474/

%0 Generic
%A Ermisch, Claudia
%D 2017
%F heidok:23178
%K Orthopädie
%T Klinisches, funktionelles und psychosoziales Outcome nach Pseudarthrosetherapie nach Masquelet-Technik
%U https://archiv.ub.uni-heidelberg.de/volltextserver/23178/

%0 Generic
%A Findeisen, Sebastian
%D 2017
%F heidok:22768
%K Orthopädie
%T Operative Behandlung von Humerusschaftpseudarthrosen angelehnt an das Diamond Concept
%U https://archiv.ub.uni-heidelberg.de/volltextserver/22768/

%0 Generic
%A Höllig, Melanie Elke
%D 2017
%F heidok:23471
%K Orthopädie
%T Histologische Evaluation der osteogenen in vivo- und in vitro-Potenz humaner mesenchymaler Stammzellen unterschiedlicher Herkunftsgewebe unter dem Einfluss von Bone Morphogenetic Protein 7
%U https://archiv.ub.uni-heidelberg.de/volltextserver/23471/

%0 Generic
%A Köhler, Christopher
%D 2017
%F heidok:23903
%K Orthopädie
%T Pseudarthroserate bei Tibiaschaftfrakturen sowie Korrelation der Kreatinkinase-Serumspiegel im zeitlichen Verlauf nach Trauma und operativer Versorgung
%U https://archiv.ub.uni-heidelberg.de/volltextserver/23903/

%0 Generic
%A Yildirim, Timur Mert
%D 2017
%F heidok:22850
%K Orthopädie
%T Ergebnisse der Behandlung posttraumatischer Pseudarthrosen mit niedrigintensivem, gepulstem Ultraschall
%U https://archiv.ub.uni-heidelberg.de/volltextserver/22850/

%0 Generic
%A Zietzschmann, Severin
%D 2017
%F heidok:23444
%K Orthopädie
%T Die Behandlung von atrophen Tibiapseudarthrosen nach dem Diamond Konzept: Ergebnisse der einzeitigen und zweizeitigen Behandlungsstrategie
%U https://archiv.ub.uni-heidelberg.de/volltextserver/23444/

%0 Generic
%A Child, Christopher
%D 2016
%F heidok:22577
%K Orthopädie
%T Inwieweit korrelieren die Serumkonzentrationen von Vascular Endothelial Growth Factor, Interferon γ, Tumor-Nekrose-Faktor α, Interleukin-1β, Interleukin-6, Interleukin-8 und Interleukin-10 mit der Remission nach traumatischer Rückenmarksverletzung
%U https://archiv.ub.uni-heidelberg.de/volltextserver/22577/

%0 Generic
%A Doll, Julian
%D 2016
%F heidok:28884
%K Orthopädie
%T Inwieweit ist der Erfolg der Knochenregeneration nach „Diamond Concept“ in unterschiedlichen Expressionsmustern von TGF-ß, PDGF-AB und IGF-1 begründet?
%U https://archiv.ub.uni-heidelberg.de/volltextserver/28884/

%0 Journal Article
%@ 1476-9255
%A Moghaddam-Alvandi, Arash
%A Breier, Lisa
%A Haubruck, Patrick
%A Bender, Daniel
%A Biglari, Bahram
%A Wentzensen, Andreas
%A Zimmermann, Gerald
%C London
%D 2016
%F heidok:20177
%I BioMed Central
%J Journal of Inflammation
%N 3
%P 1-9
%T Non-unions treated with bone morphogenic protein 7: introducing the quantitative measurement of human serum cytokine levels as promising tool in evaluation of adjunct non-union therapy
%U https://archiv.ub.uni-heidelberg.de/volltextserver/20177/
%V 13
%X Background: In this study we sought to determine if application of bone morphogenic protein 7 (BMP-7) promotes physiological bone healing of non-unions and to investigate if serum cytokine analysis may serve as a promising tool in the analysis of adjunct non-union therapy. Therefore we analyzed the influence of BMP-7 application on the serum cytokine expression patterns on patients with impaired bone healing compared to patients that showed proper bone healing.   Methods: Our study involved analyzing blood samples from 208 patients with long bone fractures together with patients that subsequently developed non-unions. From this large pool, 15 patients with atrophic non-union were matched to 15 patients with atrophic non-union treated with local application of BMP-7 as well as normal bone healing. Changes in the cytokine expression patterns were monitored during the 1st, 2nd, 4th, 8th, 12th and 52nd week. The patients were followed both clinically and radiologically for the entire duration of the study. Serum cytokine expression levels of transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) were analyzed and compared.   Results: Serum expression of TGF-β were nearly parallel in all three groups, however serum concentrations were significantly higher in patients with proper bone healing and those treated with BMP-7 than in patients with non-unions (p < 0.05). bFGF serum concentrations increased initially in patients with proper bone healing and in those treated with BMP-7. Afterwards, values decreased; bFGF serum concentrations in the BMP-7 group were significantly higher than in the other groups (p < 0.05). PDGF serum concentration levels were nearly parallel in all groups, serum concentrations were significantly higher in patients with proper bone healing and those treated with BMP-7 than in patients with non-unions (p < 0.05).   Conclusion: Treatment with BMP-7 in patients with former non-unions led to similar cytokine expression patterns after treatment as those found in patients with proper bone healing. Our results suggest that treatment with BMP-7 promote healing of non-unions. Furthermore, quantitative measurement of serum cytokine expression is a promising tool for evaluating the effectiveness of additional non-union therapies such as adjunct application of growth factors.

%0 Generic
%A Swing, Tyler
%D 2016
%F heidok:22422
%K Orthopädie
%T Temporal changes in Interleukin-1beta and Tumor necrosis factor alpha serum levels after spinal cord injury
%U https://archiv.ub.uni-heidelberg.de/volltextserver/22422/

%0 Generic
%A Teubert, Pamela
%D 2016
%F heidok:20801
%K Orthopädie
%T Eigenschaften, Differenzierungsfähigkeit und osteogene in vivo Potenz von humanen mesenchymalen Stammzellen aus unterschiedlichen Spendergeweben
%U https://archiv.ub.uni-heidelberg.de/volltextserver/20801/

%0 Generic
%A Westhauser, Fabian
%D 2016
%F heidok:22427
%K Orthopädie
%T Mikro-Computertomographische Evaluation der in-vivo Knochenbildungsfähigkeit humaner mesenchymaler Stammzellen unterschiedlicher Herkunftsgewebe unter dem Einfluss von Bone Morphogenetic Protein-7
%U https://archiv.ub.uni-heidelberg.de/volltextserver/22427/

%0 Generic
%A Xiao, Kai
%D 2016
%F heidok:20882
%K Orthopädie
%T Properties of Human Mesenchymal Stem Cells (MSC) Derived from Reamer-Irrigator-Aspirator (RIA) and Bone Marrow and the Effect of Bone Morphogenetic Protein-2 on Osteogenesis of RIA-derived MSCs (RMSC) and Bone Marrow-derived MSCs (BMSC)
%U https://archiv.ub.uni-heidelberg.de/volltextserver/20882/

%0 Generic
%A Flörsch, Stefanie
%D 2015
%F heidok:20627
%K Orthopädie
%T Evaluation der klinischen Ergebnisse eines gentamicin-beschichteten Titan-Marknagels (ETN PROtect®) zur Behandlung von Tibiafrakturen und -pseudarthrosen
%U https://archiv.ub.uni-heidelberg.de/volltextserver/20627/

%0 Generic
%A Holan, Lucia
%D 2015
%F heidok:20095
%K Orthopädie
%R 10.11588/heidok.00020095
%T Klinische Scores als prädiktive Faktoren zum Therapieerfolg von “Reamer-Irrigator-Aspirator” (RIA) zur Gewinnung von autologen mesenchymalen Stammzellen in der Therapie von Pseudarthrosen
%U https://archiv.ub.uni-heidelberg.de/volltextserver/20095/

%0 Generic
%A Kahlert, Christina
%D 2015
%F heidok:20025
%K Orthopädie
%R 10.11588/heidok.00020025
%T 3D-Bewegungsanalyse  (HUX-Modell) Deltoideopectoral- vs Minimalinvasiver Zugang bei Versorgung proximaler Humerusfrakturen mit winkelstabiler Platte (PHILOS, Synthes®)
%U https://archiv.ub.uni-heidelberg.de/volltextserver/20025/

%0 Generic
%A Raven, Tim Friedrich
%D 2015
%F heidok:20084
%K Orthopädie
%R 10.11588/heidok.00020084
%T Klinisch-funktionelles Outcome nach Plattenosteosynthese bei Radiuskopffraktur
%U https://archiv.ub.uni-heidelberg.de/volltextserver/20084/

%0 Generic
%A Büchler, Axel
%D 2014
%F heidok:16686
%K Orthopädie
%T Die Serum-Expression des löslichen CD95 Liganden während der subakuten und akuten Phase nach einer traumatischen Rückenmarksverletzung: Möglicher Ansatz für eine zielgerichtete Therapie für rückenmarksgeschädigte Patienten
%U https://archiv.ub.uni-heidelberg.de/volltextserver/16686/

%0 Generic
%A Haubruck, Patrick
%D 2014
%F heidok:17265
%K Orthopädie
%T Botulinum Neurotoxin A injection influences muscle biomechanics during stretching of the gastrocnemius muscle-tendon unit  An in vivo animal study  
%U https://archiv.ub.uni-heidelberg.de/volltextserver/17265/

%0 Generic
%A Trach, Simon
%D 2014
%F heidok:16786
%K Orthopädie
%T Physiological effects of resuscitation fluids on tissue perfusion and cardiovascular parameters
%U https://archiv.ub.uni-heidelberg.de/volltextserver/16786/

%0 Journal Article
%@ 1748-717X
%A Rief, Harald
%A Heinhold, Rita C.
%A Petersen, Lina C.
%A Rieken, Stefan
%A Bruckner, Thomas
%A Moghaddam-Alvandi, Arash
%A Debus, Jürgen
%A Sterzing, Florian
%C London
%D 2013
%F heidok:20477
%I BioMed Central
%J Radiation Oncology
%N 297
%P 1-5
%T Neurological outcome after emergency radiotherapy in MSCC of patients with non-small cell lung cancer - a prospective trial
%U https://archiv.ub.uni-heidelberg.de/volltextserver/20477/
%V 8
%X Background: The aim of this trial was to investigate neurological outcome after emergency RT in MSCC of NSCLC patients with acute neurological deficit.   Methods This pilot trial was prospective, non-randomized, and monocentre, ten patients were treated from July 2012 until June 2013. After onset of neurological symptoms RT was started within 12 hours. The neurological outcome was assessed at baseline, and six weeks after RT using the ASIA Impairment Scale (AIS).   Results: The results showed an improved neurological outcome in one patient (10%), one patient (10%) had a decreased, and five patients (50%) a constant outcome after six weeks. Three patients (30%) died within the first six weeks following RT, additional 4 patients (40%) died within 4 month due to tumor progression.   Conclusion: In this group of NSCLC patients we were able to show that emergency RT in MSCC with acute neurological deficit had no considerable benefit in neurological outcome. Therefore, short-course regime or best supportive care due to poor survival should be considered for these patients with additional distant metastases. Patients with favorable prognosis may be candidates for long-course RT.   Trial Registration: Clinical trial identifier http://www.clinicaltrials.gov/