TY - GEN Y1 - 2024/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/34535/ ID - heidok34535 AV - public TI - klinisches Outcome bei der Behandlung von Pseudarthrose nach dem ?Diamond-Konzept? KW - Orthopädie A1 - Addali, Ayoub ER - TY - GEN AV - public ID - heidok34547 Y1 - 2024/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/34547/ KW - Chirurgie TI - Die frühe operative Versorgung der akuten traumatischen Rückenmarksverletzung A1 - Bock, Tobias ER - TY - GEN KW - Orthopädie TI - Evaluation der Zytokompatibilität sowie des osteogenen und angiogenen Potentials ionischer Zersetzungsprodukte Bor-supplementierter bioaktiver Gläser in vitro und in ovo A1 - Decker, Simon Johannes AV - public ID - heidok34661 Y1 - 2024/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/34661/ ER - TY - GEN KW - Orthopädie TI - Untersuchung der osteostimulativen Eigenschaften von Vitoss® im Vergleich zu Vitoss® BA in-vivo A1 - Essers, Christopher AV - public ID - heidok34658 Y1 - 2024/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/34658/ ER - TY - GEN A1 - Reiner, Christian TI - Verursacht die Applikation von BMP-7 zur Therapie von Pseudarthrosen langer Röhrenknochen eine pathologische Zytokinexpression von IGF-1, PDGF-AB und TGF-ß? KW - Orthopädie UR - https://archiv.ub.uni-heidelberg.de/volltextserver/34544/ Y1 - 2024/// ID - heidok34544 AV - public ER - TY - GEN Y1 - 2023/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/33498/ ID - heidok33498 AV - public A1 - Heller, Raban TI - Prädiktion des neurologischen Remissionspotentials nach traumatischer Rückenmarksverletzung KW - Orthopädie ER - TY - GEN AV - public ID - heidok31749 UR - https://archiv.ub.uni-heidelberg.de/volltextserver/31749/ Y1 - 2022/// KW - Orthopädie TI - Ergebnisse nach mehrfragmentärer Radiuskopffraktur : Plattenosteosynthese vs. Endoprothese A1 - Banken, Lukas ER - TY - GEN A1 - Schönewald, Marius TI - Ein klinischer Vergleich der MoPyC®-Prothesenimplantation mit der Verwendung von winkelstabilen Implantaten bei der operativen Primärversorgung von traumatischen mehrfragmentären Radiuskopffrakturen KW - Orthopädie Y1 - 2022/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/32600/ AV - public ID - heidok32600 ER - TY - GEN A1 - Widholz, Benedikt KW - Orthopädie TI - Evaluation der osteogenen Eigenschaften des bioaktiven Borosilikatglases 0106-B1 in-vitro und in-vivo ID - heidok32960 AV - public UR - https://archiv.ub.uni-heidelberg.de/volltextserver/32960/ Y1 - 2022/// ER - TY - GEN AV - public ID - heidok31232 UR - https://archiv.ub.uni-heidelberg.de/volltextserver/31232/ Y1 - 2021/// KW - Orthopädie TI - Überlegene Bioverträglichkeit bei vergleichbaren osteogenen Eigenschaften : Natriumreduzierte Fluorid-enthaltende bioaktive Gläser aus dem CaO?MgO?SiO2-System als vielversprechende Alternative zu 45S5 bioaktivem Glas A1 - Schmitz, Sarah Isabelle ER - TY - GEN ID - heidok30665 AV - public Y1 - 2021/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/30665/ A1 - Sperl, Andre KW - Orthopädie TI - Das neuroprotektive Potential von IGF-1 analysiert an Patienten nach traumatischer Rückenmarksverletzung ER - TY - GEN A1 - Thönnes, Simon TI - Optimierung eines Sehnen- und Bandxenografts basierend auf einem aviären Sehnenscaffold KW - Orthopädie UR - https://archiv.ub.uni-heidelberg.de/volltextserver/28204/ Y1 - 2020/// ID - heidok28204 AV - public ER - TY - GEN KW - Orthopädie TI - Klinische Ergebnisse der Anwendung von ETN PROtect® in der Behandlung von Pseudarthrosen A1 - Weis, Johanna Sophia AV - public ID - heidok26591 Y1 - 2019/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/26591/ ER - TY - JOUR A1 - Haubruck, Patrick A1 - Solte, Anja A1 - Heller, Raban A1 - Daniel, Volker A1 - Tanner, Michael A1 - Moghaddam, Arash A1 - Schmidmaier, Gerhard A1 - Fischer, Christian AV - public ID - heidok25479 JF - Journal of Orthopaedic Surgery and Research Y1 - 2018/// EP - 11 PB - BioMed Central CY - London TI - Chemokine analysis as a novel diagnostic modality in the early prediction of the outcome of non-union therapy: a matched pair analysis IS - 249 N2 - Background: Despite the regenerative capability of skeletal tissue fracture, non-union is common. Treatment of non-unions remains challenging, and early determination of the outcome is impossible. Chemokines play an important role in promoting the formation of new bone and remodeling existing bone. Despite their importance regarding the regulation of bone biology, the potential of chemokines as biological markers reflecting osseous regeneration is unknown. The purpose of this study was to determine (1) if serum chemokine expression levels correlate with the outcome of non-union surgery and (2) if chemokine expression analysis can be used to identify patients at risk for treatment failure. Methods: Non-union patients receiving surgical therapy in our institution between March 2012 and March 2014 were prospectively enrolled in a clinical observer study. Regular clinical and radiological follow-up was conducted for 12 months including collection of blood during the first 12 weeks. Based on the outcome, patients were declared as responders or non-responders to the therapy. To minimize biases, patients were matched (age, sex, body mass index (BMI)) and two groups of patients could be formed: responders (R, n?=?10) and non-responders (NR, n?=?10). Serum chemokine expression (CCL-2, CCL-3, CCL-4, CXCL-10, CCL-11, and interferon gamma (IFN-?)) was analyzed using Luminex assays. Data was compared and correlated to the outcome. Results: CCL-3 expression in NR was significantly higher during the course of the study compared to R (p?=?0.002), and the expression pattern of CCL-4 correlated with CCL-3 in both groups (NR: p?<?0.001 and r?=?0.63). IFN-? expression in NR was continuously higher than in R (p?<?0.001), and utilization of CCL-3 and IFN-? serum expression levels 2 weeks after the treatment resulted in a predictive model that had an AUC of 0.92 (CI 0.74?1.00). Conclusion: Serum chemokine expression analysis over time is a valid and promising diagnostic tool. The chemokine expression pattern correlates with the outcome of the Masquelet therapy of lower limb non-unions. Utilization of the serum analysis of CCL-3 and IFN-? 2 weeks after the treatment resulted in an early predictive value regarding the differentiation between patients that are likely to heal and those that are prone to high risk of treatment failure. VL - 13 UR - https://archiv.ub.uni-heidelberg.de/volltextserver/25479/ SP - 1 SN - 1749-799X ER - TY - JOUR IS - 261 UR - https://archiv.ub.uni-heidelberg.de/volltextserver/25168/ VL - 19 N2 - Background: Bone infections due to trauma and subsequent delayed or impaired fracture healing represent a great challenge in orthopedics and trauma surgery. The prevalence of such bacterial infection-related types of delayed non-union is high in complex fractures, particularly in open fractures with additional extensive soft-tissue damage. The aim of this study was to establish a rat model of delayed osseous union secondary to bacterial osteitis and investigate the impact of rhBMP-7 and rhBMP-2 on fracture healing in the situation of an ongoing infection. Methods: After randomization to four groups 72 Sprague-Dawley rats underwent a transverse fracture of the midshaft tibia stabilized by intramedullary titanium K-wires. Three groups received an intramedullary inoculation with Staphylococcus aureus (103 colony-forming units) before stabilization and the group without bacteria inoculation served as healing control. After 5 weeks, a second surgery was performed with irrigation of the medullary canal and local rhBMP-7 and rhBMP-2 treatment whereas control group and infected control group received sterile saline. After further 5 weeks rats were sacrificed and underwent biomechanical testing to assess the mechanical stability of the fractured bone. Additional micro-CT analysis, histological, and histomorphometric analysis were done to evaluate bone consolidation or delayed union, respectively, and to quantify callus formation and the mineralized area of the callus. Results: Biomechanical testing showed a significantly higher fracture torque in the non-infected control group and the infected rhBMP-7- and rhBMP-2 group compared with the infected control group (p?<?0.001). RhBMP-7 and rhBMP-2 groups did not show statistically significant differences (p?=?0.57). Histological findings supported improved bone-healing after rhBMP treatment but quantitative micro-CT and histomorphometric results still showed significantly more hypertrophic callus tissue in all three infected groups compared to the non-infected group. Results from a semiquantitative bone-healing-score revealed best bone-healing in the non-infected control group. The expected chronic infection was confirmed in all infected groups. Conclusions: In delayed bone healing secondary to infection rhBMP treatment promotes bone healing with no significant differences in the healing efficacy of rhBMP-2 and rhBMP-7 being noted. Further new therapeutic bone substitutes should be analyzed with the present rat model for delayed osseous union secondary to bacterial osteitis. SP - 1 SN - 1471-2474 EP - 13 PB - BioMed Central TI - Bone morphogenetic proteins???7 and???2 in the treatment of delayed osseous union secondary to bacterial osteitis in a rat model CY - London ID - heidok25168 AV - public Y1 - 2018/// JF - BMC Musculoskeletal Disorders A1 - Helbig, Lars A1 - Omlor, Georg W. A1 - Ivanova, Adriana A1 - Guehring, Thorsten A1 - Sonntag, Robert A1 - Kretzer, J. Philippe A1 - Minkwitz, Susann A1 - Wildemann, Britt A1 - Schmidmaier, Gerhard ER - TY - GEN KW - Orthopädie TI - Evaluation des Einflusses der lokalen Applikation von Bone morphogenetic protein 7 auf die Angiogenese und Inflammation in der Pseudarthrosentherapie anhand von serologischer Zytokinexpressionsanalyse. A1 - Kammerer, Andreas ID - heidok25820 AV - public Y1 - 2018/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/25820/ ER - TY - GEN ID - heidok26043 AV - public Y1 - 2018/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/26043/ A1 - Prokscha, Matthäus Markus KW - Orthopädie TI - Das osteogene Potential von humanen mesenchymalen Stammzellen unterschiedlicher Herkunftsgewebe und verschiedener Knochenersatzstoffe im Rahmen des Knochen Tissue Engineerings ER - TY - GEN UR - https://archiv.ub.uni-heidelberg.de/volltextserver/24381/ Y1 - 2018/// AV - public ID - heidok24381 TI - Funktionelles und psychosoziales Outcome nach hüftgelenksnahen Frakturen Welchen Einfluss hat die Akutgeriatrische Behandlung? KW - Orthopädie A1 - Seeböck-Göbel, Thomas ER - TY - GEN Y1 - 2017/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/23474/ AV - public ID - heidok23474 A1 - Apitz, Philipp Alexander TI - Evaluation des Einflusses der Inflammationsreaktion und der Angiogenese auf das Outcome der Masquelet-Therapie anhand des Expressionsmusters der proinflammatorischen Zytokine IL-6, IL-8, TNF-alpha und des Angiogenesefaktors VEGF KW - Orthopädie ER - TY - GEN AV - public ID - heidok23178 Y1 - 2017/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/23178/ A1 - Ermisch, Claudia KW - Orthopädie TI - Klinisches, funktionelles und psychosoziales Outcome nach Pseudarthrosetherapie nach Masquelet-Technik ER - TY - GEN AV - public ID - heidok22768 Y1 - 2017/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/22768/ KW - Orthopädie TI - Operative Behandlung von Humerusschaftpseudarthrosen angelehnt an das Diamond Concept A1 - Findeisen, Sebastian ER - TY - GEN Y1 - 2017/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/23471/ ID - heidok23471 AV - public A1 - Höllig, Melanie Elke TI - Histologische Evaluation der osteogenen in vivo- und in vitro-Potenz humaner mesenchymaler Stammzellen unterschiedlicher Herkunftsgewebe unter dem Einfluss von Bone Morphogenetic Protein 7 KW - Orthopädie ER - TY - GEN KW - Orthopädie TI - Pseudarthroserate bei Tibiaschaftfrakturen sowie Korrelation der Kreatinkinase-Serumspiegel im zeitlichen Verlauf nach Trauma und operativer Versorgung A1 - Köhler, Christopher AV - public ID - heidok23903 Y1 - 2017/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/23903/ ER - TY - GEN TI - Ergebnisse der Behandlung posttraumatischer Pseudarthrosen mit niedrigintensivem, gepulstem Ultraschall KW - Orthopädie A1 - Yildirim, Timur Mert Y1 - 2017/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/22850/ ID - heidok22850 AV - public ER - TY - GEN ID - heidok23444 AV - public Y1 - 2017/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/23444/ A1 - Zietzschmann, Severin KW - Orthopädie TI - Die Behandlung von atrophen Tibiapseudarthrosen nach dem Diamond Konzept: Ergebnisse der einzeitigen und zweizeitigen Behandlungsstrategie ER - TY - GEN AV - public ID - heidok22577 Y1 - 2016/// UR - https://archiv.ub.uni-heidelberg.de/volltextserver/22577/ A1 - Child, Christopher KW - Orthopädie TI - Inwieweit korrelieren die Serumkonzentrationen von Vascular Endothelial Growth Factor, Interferon ?, Tumor-Nekrose-Faktor ?, Interleukin-1?, Interleukin-6, Interleukin-8 und Interleukin-10 mit der Remission nach traumatischer Rückenmarksverletzung ER - TY - GEN UR - https://archiv.ub.uni-heidelberg.de/volltextserver/28884/ Y1 - 2016/// AV - public ID - heidok28884 TI - Inwieweit ist der Erfolg der Knochenregeneration nach ?Diamond Concept? in unterschiedlichen Expressionsmustern von TGF-ß, PDGF-AB und IGF-1 begründet? KW - Orthopädie A1 - Doll, Julian ER - TY - JOUR A1 - Moghaddam-Alvandi, Arash A1 - Breier, Lisa A1 - Haubruck, Patrick A1 - Bender, Daniel A1 - Biglari, Bahram A1 - Wentzensen, Andreas A1 - Zimmermann, Gerald Y1 - 2016/// JF - Journal of Inflammation ID - heidok20177 AV - public PB - BioMed Central EP - 9 CY - London TI - Non-unions treated with bone morphogenic protein 7: introducing the quantitative measurement of human serum cytokine levels as promising tool in evaluation of adjunct non-union therapy UR - https://archiv.ub.uni-heidelberg.de/volltextserver/20177/ VL - 13 N2 - Background: In this study we sought to determine if application of bone morphogenic protein 7 (BMP-7) promotes physiological bone healing of non-unions and to investigate if serum cytokine analysis may serve as a promising tool in the analysis of adjunct non-union therapy. Therefore we analyzed the influence of BMP-7 application on the serum cytokine expression patterns on patients with impaired bone healing compared to patients that showed proper bone healing. Methods: Our study involved analyzing blood samples from 208 patients with long bone fractures together with patients that subsequently developed non-unions. From this large pool, 15 patients with atrophic non-union were matched to 15 patients with atrophic non-union treated with local application of BMP-7 as well as normal bone healing. Changes in the cytokine expression patterns were monitored during the 1st, 2nd, 4th, 8th, 12th and 52nd week. The patients were followed both clinically and radiologically for the entire duration of the study. Serum cytokine expression levels of transforming growth factor beta (TGF-?), platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) were analyzed and compared. Results: Serum expression of TGF-? were nearly parallel in all three groups, however serum concentrations were significantly higher in patients with proper bone healing and those treated with BMP-7 than in patients with non-unions (p?