Dissertationen der Medizinischen Fakultät

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Browse by Subject: Biotechnologie

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Number of items at this level: 58.

A

Abu-Sammour, Denis (2023) Spatial Probabilistic Mapping of Biomolecular Ensembles in Tissue via Mass Spectrometry Imaging.

B

Bauer, Andrea (2003) Genexpressionsanalysen in Karzinomen des Pankreas mittels DNA-Microarray-Technologie.

Becher, Isabelle (2013) Quantitative proteomic investigation of enzyme inhibitors for targeted therapy.

Blech, Michaela (2012) Structural and biophysical characterization of antigen : antibody binding interfaces and their potential biological implications in GM CSF and interleukin-1β signaling.

Böser, Preethne (2014) Characterization of anti-RGMa/c mAbs and their influence on iron regulation.

C

Choi, Kyeong Rok (2010) Regulation of Synaptic Plasticity in Skeletal Muscle.

D

Dittmann, Antje (2013) On the mechanism of action of small molecule therapeutics targeting histone acetylation modifiers and binders.

E

End, Caroline (2006) Untersuchungen zur Funktionsweise von Deleted in Malignant Brain Tumors 1 in der Erkennung und Abwehr von Pathogenen.

Erich, Katrin (2019) Investigation of Cancerous Tissue by MALDI Mass Spectrometry Imaging.

F

Förg, Tassilo (2015) Investigation of a possible dominant negative effect of endoglin missense mutations in Morbus Osler / Hereditary Hemorrhagic Telangiectasia (HHT).

G

Giehl, Michelle (2006) Zentrosomenaberrationen und genetische Instabilität im Verlauf der chronischen myeloischen Leukämie.

Grill, Simon (2007) Riboflavin-Biosynthese und Roseoflavin-Resistenz im Gram-positiven Bodenbakterium Streptomyces davawensis.

H

Hahnel, Wojciech (2020) Extraction of DNA from difficult samples with an automatable portable system for early detection of intestinal cancer.

Holloschi, Andreas (2007) Chorea Huntington: Zelluläres in vitro-Modell der polyglutaminabhängigen Proteinaggregation.

Honarnejad, Saman (2017) Dissecting population and single-cell heterogeneity in response to anti-cancer drugs.

Hudler, Melanie (2008) Identifizierung eines neuen Kandidaten-Onkogens.

J

Jankowitsch, Frank (2012) Die beiden terminalen Schritte der Roseoflavin-Biosynthese in Streptomyces davawensis werden von einer bisher unbekannten N,N-8-Amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) katalysiert.

K

Kara, Kerim (2020) Adaptive Collision Avoidance System for Contemporary Therapy Suites.

Keller, Florian (2021) Targeted 2D- and 3D-cell cultures reveal mechanistic effects of extracellular matrix and stromal cells on the metastatic niche formation and metabolism of cancer cells.

Kemmling, Andre (2006) Kupfer und die Alzheimersche Erkrankung: ein molekularer Link zum Amyloid-Vorläufer-Protein APP.

Klicks, Julia (2019) Development and characterization of a novel, simple, spheroid-based tri-culture model composed of fibroblasts, keratinocytes, and melanoma cells.

Kluters, Simon (2016) Modeling of pH and solvent modulated chromatography for the purification of biopharmaceuticals.

Koch, Jonas Martin Maria (2023) Mechanistic modeling and scale-up investigation of a preparative two-column purification step for a biopharmaceutical polypeptide.

Kowalski, Alexandra (2020) Development of a quick, robust and chemically-defined differentiation protocol from human induced pluripotent stem cells towards cortical neurons to phenotype Alzheimer’s Disease.

L

Lechner, Anna (2011) Regulation and genetic engineering of salinosporamide A biosynthesis.

Lee, Yi Feng (2015) Improvement of monoclonal antibody drugs by selective removal of immunogenic contaminants like multimers and host cell proteins.

M

Marsching, Christian (2014) Massenspektrometrische Analyse von Sphingolipiden der Mausniere.

Martinez, Rafael (2008) Universal microarray for analysis of breast cancer.

Maurer, Andreas Nikolas (2006) Interaktion von Chondrozyten mit Komponenten der extrazellulären Matrix : Einfluss von Erkrankung und Dedifferenzierung.

Mende, Tatjana (2022) Development and Application of a Proximity Ligation Assay for the Quantification of Synaptic Density in Mouse Models of Alzheimer’s Disease.

Menold, Hanna (2022) Retrospektive Auswertung von Krebsregisterdaten zu Diagnostik, Behandlung, Krankheitsverlauf und Outcome an Magen- oder Ösophaguskarzinomen erkrankter Patienten ≥ 75 Jahre im Vergleich mit < 75-Jährigen.

Munteanu, Bogdan (2014) Analysis of histone deacetylase drug target activation by whole- cell-MALDI-TOF mass spectrometry fingerprinting and imaging.

Mücke, Norbert (2008) Biophysikalische Untersuchung des muskelspezifischen Intermediärfilament-Proteins Desmin und Mutanten.

N

Nürnberg, Elina (2023) Optimizing Microscopy in Three Dimensions: Optical Clearing Techniques for the Study of hiPSC-Derived Neural Spheroids and 3D Cell Cultures.

P

Perrin, Jessica (2015) Development and Application of in vitro Assays for the Identification and Characterization of Kinase Inhibitors.

Ponce Moya, Leslie (2014) Establishment and characterization of an in vitro coculture model to study functional interaction between porcine keratinocytes and sensory neurites involved in cutaneous nociception.

Potempa, Marc (2010) Untersuchungen zur oxidativen in vitro Proteinrückfaltung unter Verwendung von Gemini-Disulfiddetergenzien.

R

Rabe, Jan-Hinrich (2017) Multimodal FTIR Microscopy-guided Acquisition and Interpretation of MALDI Mass Spectrometry Imaging Data.

Rey-Giraud, Flora (2012) Characterization of M-CSFR in tumorigenesis and the interactions between tumor cells and monocyte-derived macrophages in vitro.

Reyes, Gabriela Sánchez (2021) Separation and characterization of antibody-based protein variants in column chromatography for the publication of biopharmaceuticals.

Ruh, Hermelindis (2013) Identifizierung von Lipid-Biomarkern mittels MALDI-TOF Massenspektrometrie: Anwendung auf Polyzystische Nierenerkrankungen.

S

Salonikios, Theresia (2017) Automatische Datenanalyse von massenspektrometrischen Signaturen zur Klassifikation von Krebszellen und Bestimmungen von Wirkstoffwirkungen.

Schmidt, Michael (2014) Entwicklung effizienter Aufreinigungsstrategien für therapeutische Biomoleküle.

Schulz, Sandra (2016) In-situ pharmacological analysis of small molecule drugs by MALDI-TOF mass spectrometry imaging.

Schwamb, Sebastian (2015) MALDI-TOF Massenspektrometrie Biotyping – at-line Analyse von rekombinanten Zelllinien.

Schwarz, Julia (2014) Aufklärung der Biosynthese des Antibiotikums Roseoflavin aus dem Bakterium Streptomyces davawensis.

Schäfer, Maximilian E. A. (2022) Microscopic study of RNA-lipoplex-mediated cell targeting using 2D and 3D models.

Seeland, Swen (2012) How in vitro alterations in cellular energy pathways can overcome obstacles in drug research.

Seelinger, Felix (2022) Complex binding and elution behavior of therapeutic proteins under column overloading conditions.

Siebenhaar, Markus (2016) Quantitative Analyse von Störsubstanzen für Blutglukosemessungen aus dried blood spots (DBS) mittels hochauflösender Massenspektrometrie unter Umgebungsbedingungen.

Stahl, Heiko (2009) Identifizierung und funktionelle Charakterisierung von miRNAs und Oberflächenrezeptoren spezifisch für regulatorische T-Zellen.

Stange, Carolin (2023) Characterization of excipients for their application during purification of monoclonal antibodies and other therapeutic proteins.

T

Treiber, Carina (2004) Studien zur Metallionenhomöostase des Amyloid-Vorläuferproteins und des Prion-Proteins in vivo.

U

Unger, Melissa Simone (2020) Development of an Automated MALDI Mass Spectrometry Assay for Direct Analysis of Cellular Drug Uptake via the Organic Anion Transporting Polypeptide OATP2B1.

Urmann, Marina (2011) Einfluss der Oberflächenmodifikation stationärer Phasen auf Protein-Matrix-Wechselwirkungen und Massentransportprozesse in der Ionenaustauschchromatographie.

W

Werk, Tobias (2016) Optimization of heat and mass transfer, elucidation of reconstitution factors and assessing opportunities for liquid-liquid combination applications in dual chamber systems.

Wittkopp, Felix (2018) Untersuchung systematischer Zusammenhänge zwischen Chromatographie-Gel Eigenschaften und Antikörper-spezifischen Verunreinigungen in der Säulenchromatographie.

Z

Zeinali, Mina (2019) Isolation, characterization, and expansion of heterogeneous circulating tumor cell (CTC) populations from cancer patients using microfluidic technologies.