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Primary and secondary angiosarcomas: a comparative single-center analysis

Hillenbrand, Thorsten ; Menge, Franka ; Hohenberger, Peter ; Kasper, Bernd

In: Clinical Sarcoma Research, 5 (2015), Nr. 14. pp. 1-7. ISSN 2045-3329

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Abstract

Background: Angiosarcomas (AS) are rare vascular malignancies. They are subdivided into primary (PAS) and secondary angiosarcomas (SAS). The objective was to compare the characteristics of AS subtypes. Methods: Eighteen PAS and ten SAS patients treated at our institution between 2004 and 2012 were included in this study. Results: Median age of PAS and SAS patients was 52.9 and 64.2 years, respectively (p = 0.1448). The percentage of women was 27.8% for PAS, but 80.0% for SAS (p = 0.0163). While PAS occurred throughout the body, the majority of SAS arose from the breast (p = 0.0012). All SAS were radiation-induced with a median latency of 7.7 years. The majority of patients with PAS and SAS underwent surgery as primary or recurrence treatment (p > 0.95). Local recurrence was developed by 27.8% of PAS and 50.0% of SAS (p = 0.4119). 61.1% of PAS metastasized, but only 40.0% of SAS (p = 0.4328). Median overall survival for PAS and SAS was 19 and 57 months, respectively (p = 0.2306). Conclusion: Radical surgery remains the mainstay of both primary and recurrence treatment. SAS show a high local recurrence rate, while PAS tend towards developing early metastases. Overall, prognosis is poor for both groups.

Item Type: Article
Journal or Publication Title: Clinical Sarcoma Research
Volume: 5
Number: 14
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 22 Dec 2015 09:50
Date: 2015
ISSN: 2045-3329
Page Range: pp. 1-7
Faculties / Institutes: Medizinische Fakultät Mannheim > Chirurgische Klinik
Medizinische Fakultät Mannheim > Medizinische Klinik - Lehrstuhl für Innere Medizin III
Subjects: 610 Medical sciences Medicine
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