In: BMC Endocrine Disorders, 16 (2016), Nr. 56. pp. 1-7. ISSN 1472-6823

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PDF, English Download (630kB) | Lizenz: The effect of lifestyle intervention in obesity on the soluble form of activated leukocyte cell adhesion molecule by Sulaj, Alba ; Zemva, Johanna ; Zech, Ulrike ; Wöhning, Annika ; Brune, Maik ; Rudofsky, Gottfried ; Nawroth, Peter P. ; Fleming, Thomas ; von Bauer, Rüdiger underlies the terms of Creative Commons Attribution 3.0 Germany

Abstract

Background: The aim of this study was to investigate the effect of a lifestyle intervention in obesity on the soluble form of the activated leukocyte cell adhesion molecule (sALCAM) and its association with metabolic parameters. Methods: Twenty-nine obese subjects selected from the OPTIFAST®52 program. This program consisted into 2 crucial phases: an initial 12-week active weight reduction phase, followed by a 40-week weight maintenance phase. At baseline, after 12 weeks and at the end of the program, fasting glucose and insulin, total cholesterol, LDL-C, HDL-C, triglycerides, adiponectin, leptin, high sensitivity CRP, sALCAM, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and leptin-to-adiponectin-ratio were determined. Oral glucose tolerance test (OGTT) was performed when indicated. Results: At baseline, the serum concentration of sALCAM was increased and correlated positively with HOMA-IR and negatively with age. At the end of the program, sALCAM concentrations decreased significantly. Multivariate analysis showed that sALCAM significantly correlated with age, glucose concentration after 2 h OGTT and the HOMA-IR. A higher decrease of HOMA-IR during the study was observed in subjects with higher concentration of sALCAM at baseline. Conclusions: sALCAM might be a novel biomarker in obesity that correlates and predicts insulin sensitivity improvement and that can be affected by lifestyle intervention.