Directly to content
  1. Publishing |
  2. Search |
  3. Browse |
  4. Recent items rss |
  5. Open Access |
  6. Jur. Issues |
  7. DeutschClear Cookie - decide language by browser settings

Cardiometabolic risk in a population of older adults with multiple co-morbidities in rural south africa: the HAALSI (Health and Aging in Africa: longitudinal studies of INDEPTH communities) study

Gaziano, Thomas A. ; Abrahams-Gessel, Shafika ; Gomez-Olive, F. Xavier ; Wade, Alisha ; Crowther, Nigel J. ; Alam, Sartaj ; Manne-Goehler, Jennifer ; Kabudula, Chodziwadziwa W. ; Wagner, Ryan ; Rohr, Julia ; Montana, Livia ; Kahn, Kathleen ; Bärnighausen, Till W. ; Berkman, Lisa F. ; Tollman, Stephen

In: BMC Public Health, 17 (2017), Nr. 206. pp. 1-10. ISSN 1471-2458

[img]
Preview
PDF, English
Download (428kB) | Lizenz: Creative Commons LizenzvertragCardiometabolic risk in a population of older adults with multiple co-morbidities in rural south africa: the HAALSI (Health and Aging in Africa: longitudinal studies of INDEPTH communities) study by Gaziano, Thomas A. ; Abrahams-Gessel, Shafika ; Gomez-Olive, F. Xavier ; Wade, Alisha ; Crowther, Nigel J. ; Alam, Sartaj ; Manne-Goehler, Jennifer ; Kabudula, Chodziwadziwa W. ; Wagner, Ryan ; Rohr, Julia ; Montana, Livia ; Kahn, Kathleen ; Bärnighausen, Till W. ; Berkman, Lisa F. ; Tollman, Stephen underlies the terms of Creative Commons Attribution 3.0 Germany

Citation of documents: Please do not cite the URL that is displayed in your browser location input, instead use the DOI, URN or the persistent URL below, as we can guarantee their long-time accessibility.

Abstract

Background: A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults. Methods: We recruited randomly selected adults aged 40 or older residing in the rural Agincourt sub-district in Mpumalanga Province. In-person interviews were conducted to collect baseline household and socioeconomic data, self-reported health, anthropometric measures, blood pressure, high-sensitivity C-reactive protein (hsCRP), HbA1c, HIV-status, and point-of-care glucose and lipid levels. Results: Five thousand fifty nine persons (46.4% male) were enrolled with a mean age of 61.7 ± 13.06 years. Waist-to-hip ratio was high for men and women (0.92 ± 0.08 vs. 0.89 ± 0.08), with 70% of women and 44% of men being overweight or obese. Blood pressure was similar for men and women with a combined hypertension prevalence of 58.4% and statistically significant increases were observed with increasing age. High total cholesterol prevalence in women was twice that observed for men (8.5 vs. 4.1%). The prevalence of self-reported CMD conditions was higher among women, except for myocardial infarction, and women had a statistically significantly higher prevalence of angina (10.82 vs. 6.97%) using Rose Criteria. The HIV− persons were significantly more likely to have hypertension, diabetes, or be overweight or obese than HIV+ persons. Approximately 56% of the cohort had at least 2 measured or self-reported clinical co-morbidities, with HIV+ persons having a consistently lower prevalence of co-morbidities compared to those without HIV. Absolute 10-year risk cardiovascular risk scores ranged from 7.7–9.7% for women and from 12.5–15.3% for men, depending on the risk score equations used. Conclusions: This cohort has high CMD risk based on both traditional risk factors and novel markers like hsCRP. Longitudinal follow-up of the cohort will allow us to determine the long-term impact of increased lifespan in a population with both high HIV infection and CMD risk.

Item Type: Article
Journal or Publication Title: BMC Public Health
Volume: 17
Number: 206
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 22 Feb 2017 09:04
Date: 2017
ISSN: 1471-2458
Page Range: pp. 1-10
Faculties / Institutes: Medizinische Fakultät Heidelberg > Institut für Public Health (IPH)
Subjects: 610 Medical sciences Medicine
About | FAQ | Contact | Imprint |
OA-LogoDINI certificate 2013Logo der Open-Archives-Initiative