Direkt zum Inhalt
  1. Publizieren |
  2. Suche |
  3. Browsen |
  4. Neuzugänge rss |
  5. Open Access |
  6. Rechtsfragen |
  7. EnglishCookie löschen - von nun an wird die Spracheinstellung Ihres Browsers verwendet.

Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation

Witt, Stephanie H ; Frank, Josef ; Gilles, Maria ; Lang, Maren ; Treutlein, Jens ; Streit, Fabian ; Wolf, Isabell A. C. ; Peus, Verena ; Scharnholz, Barbara ; Send, Tabea S. ; Heimbach, Stefanie ; Sivalingam, Sugirthan ; Dukal, Helene ; Strohmaier, Jana ; Sütterlin, Marc ; Arloth, Janine ; Laucht, Manfred ; Nöthen, Markus M. ; Deuschle, Michael ; Rietschel, Marcella

In: BMC Genomics, 19 (2018), Nr. 290. S. 1-10. ISSN 1471-2164

[thumbnail of 12864_2018_Article_4652.pdf]
Vorschau
PDF, Englisch
Download (623kB) | Lizenz: Creative Commons LizenzvertragImpact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation von Witt, Stephanie H ; Frank, Josef ; Gilles, Maria ; Lang, Maren ; Treutlein, Jens ; Streit, Fabian ; Wolf, Isabell A. C. ; Peus, Verena ; Scharnholz, Barbara ; Send, Tabea S. ; Heimbach, Stefanie ; Sivalingam, Sugirthan ; Dukal, Helene ; Strohmaier, Jana ; Sütterlin, Marc ; Arloth, Janine ; Laucht, Manfred ; Nöthen, Markus M. ; Deuschle, Michael ; Rietschel, Marcella steht unter einer Creative Commons Namensnennung 4.0

Zitieren von Dokumenten: Bitte verwenden Sie für Zitate nicht die URL in der Adresszeile Ihres Webbrowsers, sondern entweder die angegebene DOI, URN oder die persistente URL, deren langfristige Verfügbarkeit wir garantieren. [mehr ...]

Abstract

Background: Cigarette smoking has severe adverse health consequences in adults and in the offspring of mothers who smoke during pregnancy. One of the most widely reported effects of smoking during pregnancy is reduced birth weight which is in turn associated with chronic disease in adulthood. Epigenome-wide association studies have revealed that smokers show a characteristic “smoking methylation pattern”, and recent authors have proposed that DNA methylation mediates the impact of maternal smoking on birth weight. The aims of the present study were to replicate previous reports that methylation mediates the effect of maternal smoking on birth weight, and for the first time to investigate whether the observed mediation effects are sex-specific in order to account for known sex-specific differences in methylation levels.

Methods: Methylation levels in the cord blood of 313 newborns were determined using the Illumina HumanMethylation450K Beadchip. A total of 5,527 CpG sites selected on the basis of evidence from the literature were tested. To determine whether the observed association between maternal smoking and birth weight was attributable to methylation, mediation analyses were performed for significant CpG sites. Separate analyses were then performed in males and females.

Results: Following quality control, 282 newborns eventually remained in the analysis. A total of 25 mothers had smoked consistently throughout the pregnancy. The birthweigt of newborns whose mothers had smoked throughout pregnancy was reduced by >200g. After correction for multiple testing, 30 CpGs showed differential methylation in the maternal smoking subgroup including top “smoking methylation pattern” genes AHRR, MYO1G, GFI1, CYP1A1, and CNTNAP2. The effect of maternal smoking on birth weight was partly mediated by the methylation of cg25325512 (PIM1); cg25949550 (CNTNAP2); and cg08699196 (ITGB7). Sex-specific analyses revealed a mediating effect for cg25949550 (CNTNAP2) in male newborns.

Conclusion: The present data replicate previous findings that methylation can mediate the effect of maternal smoking on birth weight. The analysis of sex-dependent mediation effects suggests that the sex of the newborn may have an influence. Larger studies are warranted to investigate the role of both the identified differentially methylated loci and the sex of the newborn in mediating the association between maternal smoking during pregnancy and birth weight.

Dokumententyp: Artikel
Titel der Zeitschrift: BMC Genomics
Band: 19
Nummer: 290
Verlag: BioMed Central ; Springer
Ort der Veröffentlichung: London ; Berlin ; Heidelberg
Erstellungsdatum: 02 Mai 2018 08:14
Erscheinungsjahr: 2018
ISSN: 1471-2164
Seitenbereich: S. 1-10
Institute/Einrichtungen: Medizinische Fakultät Heidelberg und Uniklinikum > Psychiatrische Universitätsklinik
Medizinische Fakultät Heidelberg und Uniklinikum > Psychosomatische Universitätsklinik
DDC-Sachgruppe: 610 Medizin
Leitlinien | Häufige Fragen | Kontakt | Impressum |
OA-LogoDINI-Zertifikat 2013Logo der Open-Archives-Initiative