Direkt zum Inhalt
  1. Publizieren |
  2. Suche |
  3. Browsen |
  4. Neuzugänge rss |
  5. Open Access |
  6. Rechtsfragen |
  7. EnglishCookie löschen - von nun an wird die Spracheinstellung Ihres Browsers verwendet.

Regional chemotherapy by isolated limb perfusion prior to surgery compared with surgery and post-operative radiotherapy for primary, locally advanced extremity sarcoma: a comparison of matched cohorts

Jakob, Jens ; Smith, Henry G. ; Wilkinson, Michelle J. ; Pencavel, Tim ; Miah, Aisha B. ; Thomas, Joseph M. ; Tunn, Per-Ulf ; Pilz, Lothar R. ; Strauss, Dirk C. ; Hohenberger, Peter ; Hayes, Andrew J.

In: Clinical Sarcoma Research, 8 (2018), Nr. 12. S. 1-9. ISSN 2045-3329

[thumbnail of 13569_2018_Article_98.pdf]
Vorschau
PDF, Englisch
Download (1MB) | Lizenz: Creative Commons LizenzvertragRegional chemotherapy by isolated limb perfusion prior to surgery compared with surgery and post-operative radiotherapy for primary, locally advanced extremity sarcoma: a comparison of matched cohorts von Jakob, Jens ; Smith, Henry G. ; Wilkinson, Michelle J. ; Pencavel, Tim ; Miah, Aisha B. ; Thomas, Joseph M. ; Tunn, Per-Ulf ; Pilz, Lothar R. ; Strauss, Dirk C. ; Hohenberger, Peter ; Hayes, Andrew J. steht unter einer Creative Commons Namensnennung 3.0 Deutschland

Zitieren von Dokumenten: Bitte verwenden Sie für Zitate nicht die URL in der Adresszeile Ihres Webbrowsers, sondern entweder die angegebene DOI, URN oder die persistente URL, deren langfristige Verfügbarkeit wir garantieren. [mehr ...]

Abstract

Background: Induction chemotherapy by isolated limb perfusion (ILP) with melphalan and tumour necrosis factor-α is an effective strategy to facilitate limb-conserving surgery in locally advanced extremity sarcoma. In a comparison of cohorts matched for grade, size and surgical resectability, we compared the outcome of patients undergoing induction ILP prior to limb-conserving surgery and selective post-operative radiotherapy with patients undergoing limb-conserving surgery and routine post-operative radiotherapy.

Methods: Patients with primary, grade 2/3 sarcomas of the lower limbs over 10 cm in size were identified from prospectively maintained databases at 3 centres. Patients treated at a UK centre underwent limb-conserving surgery and post-operative radiotherapy (Standard cohort). Patients at two German centres underwent induction ILP, limb-conserving surgery and selective post-operative radiotherapy (ILP cohort).

Results: The Standard cohort comprised 80 patients and the ILP cohort 44 patients. Both cohorts were closely matched in terms of tumour size, grade, histological subtype and surgical resectability. The median age was greater in the Standard vs the ILP cohort (60.5 years vs 56 years, p = 0.033). The median size was 13 cm in both cohorts. 5-year local-recurrence (ILP 12.2%, Standard 20.1%, p = 0.375) and distant metastases-free survival rates (ILP 49.6%, Standard 46.0% p = 0.821) did not differ significantly between cohorts. Fewer patients received post-operative radiotherapy in the ILP cohort compared with the Standard cohort (27% vs 82%, p < 0.001).

Conclusion: In comparative cohorts, the outcomes of patients undergoing induction ILP prior to surgery did not differ from those undergoing standard management, although induction ILP was associated with a reduced need for adjuvant radiation.

Dokumententyp: Artikel
Titel der Zeitschrift: Clinical Sarcoma Research
Band: 8
Nummer: 12
Verlag: BioMed Central
Ort der Veröffentlichung: London
Erstellungsdatum: 10 Jul. 2018 12:52
Erscheinungsjahr: 2018
ISSN: 2045-3329
Seitenbereich: S. 1-9
Institute/Einrichtungen: Medizinische Fakultät Heidelberg und Uniklinikum > Orthopädische Klinik
DDC-Sachgruppe: 610 Medizin
Leitlinien | Häufige Fragen | Kontakt | Impressum |
OA-LogoDINI-Zertifikat 2013Logo der Open-Archives-Initiative