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An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial

Karusheva, Yanislava ; Kunstein, Lejla ; Bierwagen, Alessandra ; Nowotny, Bettina ; Kabisch, Stefan ; Groener, Jan B. ; Fleitmann, Ann Kristin ; Herder, Christian ; Pacini, Giovanni ; Strassburger, Klaus ; Häring, Hans-Ulrich ; Nawroth, Peter P. ; Pfeiffer, Andreas F. H. ; Burkart, Volker ; Müssig, Karsten ; Roden, Michael ; Szendroedi, Julia

In: Nutrition & Metabolism, 15 (2018), Nr. 90. S. 1-8. ISSN 1743-7075

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Download (776kB) | Lizenz: Creative Commons LizenzvertragAn 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial von Karusheva, Yanislava ; Kunstein, Lejla ; Bierwagen, Alessandra ; Nowotny, Bettina ; Kabisch, Stefan ; Groener, Jan B. ; Fleitmann, Ann Kristin ; Herder, Christian ; Pacini, Giovanni ; Strassburger, Klaus ; Häring, Hans-Ulrich ; Nawroth, Peter P. ; Pfeiffer, Andreas F. H. ; Burkart, Volker ; Müssig, Karsten ; Roden, Michael ; Szendroedi, Julia steht unter einer Creative Commons Namensnennung 4.0

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Abstract

Background: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D.

Methods: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention.

Results: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention.

Conclusions: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes.

Trial registration: Registration at Clinicaltrials.gov, Identifier number: NCT01409330 , Registered 4 August 2011 – Retrospectively registered.

Dokumententyp: Artikel
Titel der Zeitschrift: Nutrition & Metabolism
Band: 15
Nummer: 90
Verlag: BioMed Central
Ort der Veröffentlichung: London
Erstellungsdatum: 10 Jan. 2019 10:15
Erscheinungsjahr: 2018
ISSN: 1743-7075
Seitenbereich: S. 1-8
Institute/Einrichtungen: Medizinische Fakultät Heidelberg und Uniklinikum > Medizinische Universitäts-Klinik und Poliklinik
DDC-Sachgruppe: 610 Medizin
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