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Development of breast cancer mortality considering the implementation of mammography screening programs – a comparison of western European countries

Iwamoto, Yukio ; Kaucher, Simone ; Lorenz, Eva ; Bärnighausen, Till ; Winkler, Volker

In: BMC Public Health, 19 (2019), Nr. 823. pp. 1-9. ISSN 1471-2458

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Abstract

Background: Triggered by the successive implementation of organized mammography screening programs (MSPs) throughout western European countries over the last decades, there is an ongoing debate questioning their effectiveness. Since it is difficult to assess the effect of MSPs on a population level, we rather aim to assess the impact of the implementation itself on breast cancer mortality rates utilizing an ecological study design.

Methods: We analyzed age group-specific (50–59, 60–69 and 70–79 years) female breast cancer mortality rates in 14 western European countries between 1980 and 2017 using Joinpoint regression, interrupted time series (ITS) regression and multivariable Poisson regression.

Results: The Joinpoint analysis demonstrated decreasing trends resulting in annual percentage changes ranging from − 1.5% to − 5.4% (50–59), − 0.2% to − 8.1% (60–69) and 0% to − 7.1% (70–79) depending on the country within 3 years after MSP implementation. The ITS analysis results in highly significant interaction terms (calendar year * binary MSP indicator) for all age groups. The multivariable regression using “calendar year”, “year of MSP implementation” and “years with MSP” as independent variables yielded a significant yearly decrease for “years with MSP” ranging from 0.9 to 1.2%.

Conclusions: The results of this study suggest a positive association between the implementation of MSPs and the (accelerated) reduction of breast cancer mortality rates. Measuring and quantifying the isolated effect of MSPs on a population level will require additional studies using individual data.

Item Type: Article
Journal or Publication Title: BMC Public Health
Volume: 19
Number: 823
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 09 Aug 2019 10:43
Date: 2019
ISSN: 1471-2458
Page Range: pp. 1-9
Faculties / Institutes: Medizinische Fakultät Heidelberg > Institut für Public Health (IPH)
Subjects: 610 Medical sciences Medicine
Uncontrolled Keywords: Breast cancer, Mortality, Mammography screening, Europe
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