Ability of chlorhexidine, octenidine, polyhexanide and chloroxylenol to inhibit metabolism of biofilm-forming clinical multidrug-resistant organisms

Günther, Frank ; Blessing, Brigitte ; Dapunt, Ulrike ; Mischnik, Alexander ; Mutters, Nico T.

In: Journal of Infection Prevention, 22 (2021), Nr. 1. pp. 12-18. ISSN 1757-1774 (Druck-Ausg.); 1757-1782 (Online-Ausg.)

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Official URL: https://doi.org/10.1177/1757177420963829

Citation of documents: Please do not cite the URL that is displayed in your browser location input, instead use the DOI, URN or the persistent URL below, as we can guarantee their long-time accessibility.

DOI: 10.11588/heidok.00029374
URN: urn:nbn:de:bsz:16-heidok-293749
URL: http://www.ub.uni-heidelberg.de/archiv/29374

Abstract

Purpose: This in vitro study was designed to determine if standard antiseptics used for skin and environmental surface cleansing can disrupt the metabolic activity (as a measure of viability) of multidrug-resistant gram-negative bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus isolates within their native biofilms.

Methods: Sixty clinical isolates of multidrug-resistant bacteria were selected for testing in different chlorhexidine gluconate, octenidine, polyhexanide and chloroxylenol concentrations. Metabolic inhibition of biofilm for each clinical isolate was analysed using a biofilm viability assay.

Results: Chlorhexidine gluconate (mean = 83.8% ± 9.8%) and octenidine (mean = 84.5% ± 6.8%) showed the greatest efficacy against biofilms of the tested microorganisms, with the greatest efficacies against MRSA. The antiseptics demonstrated the least efficacy against biofilms of Pseudomonas aeruginosa.

Conclusion: Chlorhexidine gluconate and octenidine showed the greatest level of bacterial metabolic inhibition and were statistically equivalent. Polyhexanide was more effective than chloroxylenol, but both were inferior to chlorhexidine gluconate and octenidine against the tested organisms.

Document type:	Article
Journal or Publication Title:	Journal of Infection Prevention
Volume:	22
Number:	1
Publisher:	Sage
Place of Publication:	London
Edition:	Zweitveröffentlichung
Date Deposited:	09 Feb 2021 16:52
Date:	2021
ISSN:	1757-1774 (Druck-Ausg.); 1757-1782 (Online-Ausg.)
Page Range:	pp. 12-18
Faculties / Institutes:	Medizinische Fakultät Heidelberg > Orthopädische Klinik Medizinische Fakultät Heidelberg > Department for Infectiology
DDC-classification:	610 Medical sciences Medicine
Uncontrolled Keywords:	Chlorhexidine, octenidine, multidrug resistant gram-negatives, hospital-acquired infection, MRSA, biofilm
Additional Information:	Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.