In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 58 (2021), Nr. 4. pp. 270-279. ISSN 0004-5632 (Druck-Ausg.), 1758-1001 (Online-Ausg.)
Preview |
PDF, English
- main document
Download (471kB) | Terms of use |
Abstract
Background: Data is limited evaluating novel biomarkers in right ventricular dysfunction. Normal right heart function improves the prognosis of patients with heart failure. Therefore, this study investigates the association between the novel biomarker copeptin and right heart function compared to NT-proBNP.
Methods: Patients undergoing routine echocardiography were enrolled prospectively. Right ventricular function was assessed by tricuspid annular plane systolic excursion (TAPSE) and further right ventricular and atrial parameters. Exclusion criteria were age under 18 years, left ventricular ejection fraction < 50% and moderate to severe valvular heart disease. Blood samples were taken for biomarker measurements within 72 h of echocardiography.
Results: Ninety-one patients were included. Median values of copeptin increased significantly according to decreasing values of TAPSE (P = 0.001; right heart function grade I: tricuspid annular plane systolic excursion; TAPSE > 24 mm: 5.20 pmol/L; grade II: TAPSE 18–24 mm: 8.10 pmol/L; grade III: TAPSE < 18 mm: 26.50 pmol/L). Copeptin concentrations were able to discriminate patients with decreased right heart function defined as TAPSE < 18 mm (area under the curves [AUC]: copeptin: 0.793; P = 0.001; NT-proBNP: 0.805; P = 0.0001). Within a multivariable linear regression model, copeptin was independently associated with TAPSE (copeptin: T: –4.43; P = 0.0001; NT-proBNP: T: –1.21; P = 0.23). Finally, copeptin concentrations were significantly associated with severely reduced right heart function (TAPSE < 18 mm) within a multivariate logistic regression model (copeptin: odds ratio: 0.94; 95% confidence interval: 0.911–0.975; P = 0.001).
Conclusions: This study demonstrates that the novel biomarker copeptin reflects longitudinal right heart function assessed by standardized transthoracic echocardiography compared with NT-proBNP.
Document type: | Article |
---|---|
Journal or Publication Title: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine |
Volume: | 58 |
Number: | 4 |
Publisher: | Sage |
Place of Publication: | London |
Edition: | Zweitveröffentlichung |
Date Deposited: | 16 Jul 2021 08:16 |
Date: | 2021 |
ISSN: | 0004-5632 (Druck-Ausg.), 1758-1001 (Online-Ausg.) |
Page Range: | pp. 270-279 |
Faculties / Institutes: | Medizinische Fakultät Mannheim > Medizinische Klinik - Lehrstuhl für Innere Medizin I |
DDC-classification: | 610 Medical sciences Medicine |
Uncontrolled Keywords: | Copeptin, diagnosis, right heart failure, right heart function, right ventricle |
Additional Information: | Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. |