Impact of disease-modifying therapies on evolving tissue damage in iron rim multiple sclerosis lesions

Eisele, Philipp ; Wittayer, Matthias ; Weber, Claudia E. ; Platten, Michael ; Schirmer, Lucas ; Gass, Achim

In: Multiple Sclerosis Journal, 28 (2022), Nr. 14. pp. 2294-2298. ISSN 1352-4585 (Druck-Ausg.); 1477-0970 (Online-Ausg.)

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Official URL: https://doi.org/10.1177/13524585221106338

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DOI: 10.11588/heidok.00032917
URN: urn:nbn:de:bsz:16-heidok-329174
URL: http://www.ub.uni-heidelberg.de/archiv/32917

Abstract

We investigated the impact of disease-modifying therapies (DMTs) on the evolving tissue damage in iron rim multiple sclerosis lesions using a novel post-processing magnetic resonance imaging (MRI) approach, the T1/T2 ratio. In this study, on baseline and 1-year follow-up, T1/T2 ratios of iron rim lesions (IRLs) in patients starting DMT (dimethyl fumarate, fingolimod, ocrelizumab) did not statistically differ compared to patients without DMT. At the second follow-up, T1/T2 ratios were significantly lower in IRLs in patients without DMT (p = 0.002), suggesting that DMTs have a beneficial delayed effect on lesion evolution and tissue matrix damage in IRLs.

Document type:	Article
Journal or Publication Title:	Multiple Sclerosis Journal
Volume:	28
Number:	14
Publisher:	Sage
Place of Publication:	London
Edition:	Zweitveröffentlichung
Date Deposited:	22 Feb 2023 08:05
Date:	2022
ISSN:	1352-4585 (Druck-Ausg.); 1477-0970 (Online-Ausg.)
Page Range:	pp. 2294-2298
Faculties / Institutes:	Medizinische Fakultät Mannheim > Neurologische Klinik
DDC-classification:	610 Medical sciences Medicine
Additional Information:	Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.