In: European Journal of Ophthalmology, 34 (2024), Nr. 2. pp. 487-496. ISSN 1120-6721 (Druck-Ausg.); 1724-6016 (Online-Ausg.)
Preview |
PDF, English
- main document
Download (1MB) | Terms of use |
Abstract
Purpose To analyze anatomic and functional response to intravitreal brolucizumab in age-related macular degeneration recalcitrant to previous intravitreal anti-VEGF therapies. Methods In this monocentric, one arm, retrospective study, eyes affected by neovascular age-related macular degeneration (nAMD) resistant to other intravitreally injected anti-vascular endothelial growth factor inhibitors were switched to intravitreal brolucizumab. All patients underwent ophthalmological examinations at baseline and in regular follow-up intervals. Best registered visual acuity (BRVA), Goldmann tonometry, intraocular pressure (IOP), central retinal thickness (CRT) and pigment epithelial detachment (PED) characteristics were analyzed at initiation of anti-VEGF treatment, at treatment switch, and at the end of brolucizumab loading phase. Results The study included 20 eyes of 18 consecutively treated patients (age: 77 ± 6 years). All eyes had macular neovascularization with PED. Previous treatments included intravitreal aflibercept, bevacizumab, and ranibizumab and had not resulted in a significant improvement in BRVA (0.5 ± 0.5 logMAR vs 0.5 ± 0.6 logMAR) or mean CRT (320 ± 60 µm vs 313 ± 83 µm) up to treatment switch to brolucizumab. At the end of the brolucizumab loading phase, there was significant improvement for both BRVA (0.3 ± 0.2 logMAR, P < 0.05) and CRT (264 ± 55 µm, P < 0.05). Under previous anti-VEGF therapy, there was a significant increase/deterioration in both PED area (2.68 mm 2 to 5.18 mm 2 , P < 0.05) and PED volume (0.39 mm 3 to 1.07 mm 3 , P < 0.05); however, both parameters improved after switching to brolucizumab (3.81 mm 2 and 0.37 mm 3 , P < 0.05). Conclusion
Our results suggest a favourable anatomical and visual response after treatment switch to brolucizumab in patients with nAMD refractory to previous anti-VEGF agents.
Document type: | Article |
---|---|
Journal or Publication Title: | European Journal of Ophthalmology |
Volume: | 34 |
Number: | 2 |
Publisher: | Sage Publications Ltd. |
Place of Publication: | London |
Edition: | Zweitveröffentlichung |
Date Deposited: | 26 Apr 2024 12:45 |
Date: | 2024 |
ISSN: | 1120-6721 (Druck-Ausg.); 1724-6016 (Online-Ausg.) |
Number of Pages: | 10 |
Page Range: | pp. 487-496 |
Faculties / Institutes: | Medizinische Fakultät Mannheim > Augenklinik |
DDC-classification: | 610 Medical sciences Medicine |
Additional Information: | Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. *** This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. |