Direkt zum Inhalt
  1. Publizieren |
  2. Suche |
  3. Browsen |
  4. Neuzugänge rss |
  5. Open Access |
  6. Rechtsfragen |
  7. EnglishCookie löschen - von nun an wird die Spracheinstellung Ihres Browsers verwendet.

Learning and memory in molecular networks

Lissek, Thomas

[thumbnail of Lissek_Learning_memory_molecular_networks_2025.pdf]
Vorschau
PDF, Englisch - Hauptdokument
Download (269kB) | Lizenz: Creative Commons LizenzvertragLearning and memory in molecular networks von Lissek, Thomas steht unter einer Creative Commons Namensnennung 4.0

Zitieren von Dokumenten: Bitte verwenden Sie für Zitate nicht die URL in der Adresszeile Ihres Webbrowsers, sondern entweder die angegebene DOI, URN oder die persistente URL, deren langfristige Verfügbarkeit wir garantieren. [mehr ...]

Abstract

The present work examines the capacity of biological systems to encode memories via adaptive changes in molecular networks. In single cells, the rewiring of molecular networks can store information as molecular engrams. In multicellular organisms, single cells might communicate with each other and tune their molecular memories to cooperatively encode multicellular memories in tissues and organs. Learning in the whole brain might consequently be examined as a problem of individual cells learning how to form a memory together via tuning their single-cell memories to each other and a significant amount of memory content in the brain might be stored at the molecular level inside of single cells. Molecular memory formation is proposed as a universal concept to explain adaptive organism phenotypes and can elucidate memory phenomena in the brain, immune system, skeletal muscle, skin, endocrine system and during development among others. Consequently, the formation of maladaptive memories in different tissues can explain stable, environmentally-induced dysfunction in various human diseases including cancer, autoimmunity, addiction, post-traumatic stress disorder, obesity, diabetes and fibrosis. The targeting of physiological molecular memories and the creation of synthetic memories could be valuable strategies to influence organism physiology in biological engineering and therapeutic interventions.

Dokumententyp: Preprint
Ort der Veröffentlichung: Heidelberg
Erstellungsdatum: 30 Jun. 2025 08:59
Erscheinungsjahr: 2025
Institute/Einrichtungen: Zentrale und Sonstige Einrichtungen > Interdisziplinäres Zentrum für Neurowissenschaften
DDC-Sachgruppe: 570 Biowissenschaften, Biologie
610 Medizin
Leitlinien | Häufige Fragen | Kontakt | Impressum |
OA-LogoDINI-Zertifikat 2013Logo der Open-Archives-Initiative