In: International Journal of Pediatric Endocrinology, New York; Berlin; Heidelberg (2010), S. 1-7. ISSN 1687-9856

Vorschau

PDF, Englisch Download (230kB) | Lizenz: Nutritional rickets among children in a sun rich country (clinical study) von Bener, Abdulbari ; Hoffmann, Georg F. steht unter einer Creative Commons Namensnennung 3.0 Deutschland

Abstract

Objective: This study describes the magnitude and characteristics of nutritional rickets and associated risk factors among children in Qatar. Subjects: A consecutive sample of 730 healthy subjects who visited the primay health care clinics were approached and 540 (73.9%) subjects gave consent. Mehods: Nutritional rickets diagnosis was based on clinical radiologic and biochemical parameters and normalization of alkaline phosphatase level after 6 weeks course of daily vitamin D therapy. Results: The study revealed that 23.9% of the studied children had nutritional rickets. The mean SD age of those with rickets (3.76 years 1.51) was slightly higher than those without rickets (3.57 years 1.45). Family history of vitamin D deficiency (44.2%; P = .001) and diabetes mellitus (53.5%; P = .002) were significantly higher in rachitic children than in nonrachitic children. The children with rickets spent a significantly shorter average duration (26.86 minutes 19.94) under the sun than those without rickets (30.59 minutes 15.72; p < .001). A significantly larger proportion of rachitic children was afflicted with vitamin D deficiency (75.2% versus 62.2%; p < .001), secondary hypothyroidism (100% versus 7.5%; P = .009) and muscular weakness (56.6% versus 26.3%; p < .001). Conclusion: The most important risk factors were low vitamin D and calcium intakes, lack of exposure to sunlight, prolonged breast feeding without supplementation of vitamin D.