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Pseudobacteremia outbreak of biofilm-forming Achromobacter xylosoxidans – environmental transmission

Günther, Frank ; Merle, Uta ; Frank, Uwe ; Gaida, Matthias M. ; Mutters, Nico T.

In: BMC Infectious Diseases, 16 (2016), Nr. 584. S. 1-5. ISSN 1471-2334

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Abstract

Background: Achromobacter xylosoxidans (AX) is known for intrinsic resistance to disinfectants. Our laboratory routine surveillance system detected an unexpected rise in AX bloodstream infections in a 2200-bed hospital. An epidemiological investigation was conducted to find the source and disrupt further transmission. Methods: Outbreak cases were defined as patients with at least one positive blood culture positive for AX from May 2014 to May 2015. Medical records were reviewed, affected wards, as well as the microbiology laboratory were audited. Additionally, microbiologic culture and biofilm staining for suspected antiseptic reusable tissue dispensers were performed, and isolated AX strains were typed using RAPD PCR and PFGE. Results: During the outbreak period, AX were isolated from blood cultures from 26 patients. The retrospective cohort study did not reveal common risk factors. The clinical features of the case patients suggested a pseudobacteremia. The reusable tissue dispensers containing Incidin® Plus solution product were found to be contaminated with biofilm-forming AX. Typing of the isolates revealed that blood culture isolates were identical with the strains found in the dispensers. Conclusions: After changing the usage of the product to single-use and educating staff, the outbreak was terminated. Contamination of dispensers occurred due to insufficient reprocessing, since biofilm disrupting steps were not included in the process.

Dokumententyp: Artikel
Titel der Zeitschrift: BMC Infectious Diseases
Band: 16
Nummer: 584
Verlag: BioMed Central; Springer
Ort der Veröffentlichung: London; Berlin; Heidelberg
Erstellungsdatum: 26 Okt. 2016 12:42
Erscheinungsjahr: 2016
ISSN: 1471-2334
Seitenbereich: S. 1-5
Institute/Einrichtungen: Medizinische Fakultät Heidelberg und Uniklinikum > Medizinische Universitäts-Klinik und Poliklinik
Medizinische Fakultät Heidelberg und Uniklinikum > Department für Infektiologie
Medizinische Fakultät Heidelberg und Uniklinikum > Pathologisches Institut
DDC-Sachgruppe: 610 Medizin
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