Directly to content
  1. Publishing |
  2. Search |
  3. Browse |
  4. Recent items rss |
  5. Open Access |
  6. Jur. Issues |
  7. DeutschClear Cookie - decide language by browser settings

Verbesserung der intestinalen Resorption von Peptidwirkstoffen mit Hilfe von Gallensäuren, insbesondere Cholylsarcosin

Michael, Susanne

English Title: Improvement of the intestinal resorption of peptide drugs with bile acids especially Cholylsarcosine

PDF, German
Download (15MB) | Terms of use

Citation of documents: Please do not cite the URL that is displayed in your browser location input, instead use the DOI, URN or the persistent URL below, as we can guarantee their long-time accessibility.


Thema dieser Dissertation war die Untersuchung des Einflusses von Cholylsarcosin-Na auf die Aufnahme von Peptiden aus dem Darm. Vergleichend dazu sollten natürliche Gallensalze als Resorptionsenhancer getestet werden. Die resorptionsverbessernden Eigenschaften von Cholylsarcosin-Na (CS-Na) wurden im Verhältnis zu CDCA-Na, TC-Na und UDCA-Na beurteilt. Es konnte gezeigt werden, daß eine 1 ige Lösung von CS-Na den Transport der Modellpeptide, Desmopressin und Octreotid, durch CaCo-2 Monolayer verbessert.

Translation of abstract (English)

The subject of this thesis was to study the influence of cholylsarcosin-Na (CS-Na) on the uptake of peptides out of the intestinal lumen. In comparison to this natural bile salts were tested as resorption enhancers. The results showed that CS-Na is a promising resorption enhancer for the modell peptides testet e.g. desmopressine and octreotide.

Item Type: Dissertation
Supervisor: Fricker, Prof. Dr. Gert,
Date of thesis defense: 15 December 2000
Date Deposited: 05 Jan 2001 00:00
Date: 2000
Faculties / Institutes: The Faculty of Bio Sciences > Institute of Pharmacy and Molecular Biotechnology
Subjects: 540 Chemistry and allied sciences
Controlled Keywords: Resorption, Gallensalze, Peptide
Uncontrolled Keywords: Resorptionsverbesserung, Cholylsarcosincholylsarcosine, resorption enhancement
Additional Information: Teile in: European Journal of Pharmaceutical Sciences
About | FAQ | Contact | Imprint |
OA-LogoDINI certificate 2013Logo der Open-Archives-Initiative