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Coexisting large and small vessel disease in patients with ischemic stroke of undetermined cause

Chatzikonstantinou, Anastasios ; Krissak, Radko ; Schaefer, A. ; Schönberg, Stefan O. ; Fink, Christian ; Hennerici, Michael G.

In: European neurology, 68 (2012), Nr. 3. pp. 162-165. ISSN 0014-3022

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Background and Purpose: Large artery atherosclerosis (LAA) and small vessel disease (SVD) share common risk factors for stroke. We aimed at investigating the association of SVD with cerebral LAA as well as with atherosclerosis in patients with stroke likely to originate from aortic plaques. Methods: We investigated 71 consecutive patients (48 men, mean age 64.2 +/- 13 years) with ischemic stroke of undetermined cause according to the ASCO classification, who received ECG-triggered CT angiography for best available atherosclerotic plaque detection in the aorta. Results: Aortic atherosclerotic plaques were detected in 54 patients (76.1%). The presence of SVD significantly correlated with the presence of aortic plaques (p < 0.001), as well as LAA (p < 0.001) and risk factors such as arterial hypertension (p = 0.032) and diabetes mellitus (p = 0.017). Conclusions: Aortic plaques are common in patients with stroke of undetermined cause. If so, SVD and LAA are often coexisting, which demonstrates the close link of macro- and microangiopathy, at least in cases of severe risk factors of atherosclerosis. Copyright © 2012 S. Karger AG, Basel

Item Type: Article
Journal or Publication Title: European neurology
Volume: 68
Number: 3
Publisher: S. Karger AG
Date Deposited: 22 Dec 2014 07:44
Date: 2012
ISSN: 0014-3022
Page Range: pp. 162-165
Faculties / Institutes: Medizinische Fakultät Mannheim > Institut für Klinische Radiologie
Medizinische Fakultät Mannheim > Neurologische Klinik
Subjects: 610 Medical sciences Medicine
Controlled Keywords: Arteriosklerose, Schlaganfall
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